Ten children with asymptomatic persistent cryptogenic increased serum levels of aspartate aminotransferase (AST) were screened for detection and monitoring of AST macroenzyme (macroAST). MacroAST was found in 4 patients; their serum AST levels were significantly higher than in those without biochemical evidence of macroAST (mean +/- SD: 515 +/- 433 and 78 +/- 16 IU/L, respectively; P = .0095). MacroAST was a persistent, benign phenomenon and was probably not congenital.
Macroenzyme investigation and monitoring in children with persistent increase of aspartate aminotransferase of unexplained origin / Fortunato, G; Iorio, Raffaele; Esposito, P; Lofrano, Mm; Vegnente, A; Vajro, P.. - In: THE JOURNAL OF PEDIATRICS. - ISSN 0022-3476. - STAMPA. - 133:(1998), pp. 286-289. [10.1016/S0022-3476(98)70238-0]
Macroenzyme investigation and monitoring in children with persistent increase of aspartate aminotransferase of unexplained origin.
FORTUNATO G;IORIO, RAFFAELE;
1998
Abstract
Ten children with asymptomatic persistent cryptogenic increased serum levels of aspartate aminotransferase (AST) were screened for detection and monitoring of AST macroenzyme (macroAST). MacroAST was found in 4 patients; their serum AST levels were significantly higher than in those without biochemical evidence of macroAST (mean +/- SD: 515 +/- 433 and 78 +/- 16 IU/L, respectively; P = .0095). MacroAST was a persistent, benign phenomenon and was probably not congenital.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
