The Mediterranean sponge Axinella verrucosa has been investigated for its alkaloid composition and has been found to produce a complex mixture of bromopyrrole alkaloids. Along with the previously isolated compounds 5–18, four novel alkaloids of this class, compounds 1–4, have been isolated, and their structures established through spectroscopic methods. Compounds 1–4 were found to display neuroprotective activity against the agonists serotonin and glutamate in vitro.
Novel bioactive bromopyrrole alkaloids from the Mediterranean sponge Axinella verrucosa / Aiello, Anna; M., D'Esposito; Fattorusso, Ernesto; Menna, Marialuisa; W. E. G., Mueller; S., PEROVIC OTTSTADT; H. C., Schroeder. - In: BIOORGANIC & MEDICINAL CHEMISTRY. - ISSN 0968-0896. - STAMPA. - 14:(2006), pp. 17-24. [10.1016/j.bmc.2005.07.057]
Novel bioactive bromopyrrole alkaloids from the Mediterranean sponge Axinella verrucosa
AIELLO, ANNA;FATTORUSSO, ERNESTO;MENNA, MARIALUISA;
2006
Abstract
The Mediterranean sponge Axinella verrucosa has been investigated for its alkaloid composition and has been found to produce a complex mixture of bromopyrrole alkaloids. Along with the previously isolated compounds 5–18, four novel alkaloids of this class, compounds 1–4, have been isolated, and their structures established through spectroscopic methods. Compounds 1–4 were found to display neuroprotective activity against the agonists serotonin and glutamate in vitro.| File | Dimensione | Formato | |
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