An improved synthesis of 1 (R = SiPh2CMe3, R1 = SiMe2CMe3) which contains the C23-C35 moiety of reidispongiolide A, was completed. An intermol. Nozaki-Hiyama-Kishi coupling was employed for the union of C23-C30 and C31-C35 fragments. A discussion on the factors influencing the stereochem. outcome of (E)-crotylboration reactions of alpha-methyl-beta-alkoxy aldehydes was also presented.
Toward the synthesis of reidispongiolide A: An improved stereocontrolled synthesis of the C23-C35 fragment of reidispongiolide A / Zampella, Angela; Sepe, Valentina; D'Orsi, R.; D'Auria, MARIA VALERIA. - In: LETTERS IN ORGANIC CHEMISTRY. - ISSN 1570-1786. - STAMPA. - 1:4(2004), pp. 308-312. [10.2174/1570178043400523]
Toward the synthesis of reidispongiolide A: An improved stereocontrolled synthesis of the C23-C35 fragment of reidispongiolide A
ZAMPELLA, ANGELA;SEPE, VALENTINA;D'AURIA, MARIA VALERIA
2004
Abstract
An improved synthesis of 1 (R = SiPh2CMe3, R1 = SiMe2CMe3) which contains the C23-C35 moiety of reidispongiolide A, was completed. An intermol. Nozaki-Hiyama-Kishi coupling was employed for the union of C23-C30 and C31-C35 fragments. A discussion on the factors influencing the stereochem. outcome of (E)-crotylboration reactions of alpha-methyl-beta-alkoxy aldehydes was also presented.| File | Dimensione | Formato | |
|---|---|---|---|
|
LOC_2004.pdf
accesso aperto
Tipologia:
Documento in Pre-print
Licenza:
Accesso privato/ristretto
Dimensione
117.19 kB
Formato
Adobe PDF
|
117.19 kB | Adobe PDF | Visualizza/Apri |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
