We have isolated a rat thyroid cDNA encoding a novel rat receptor-type tyrosine phosphatase protein. This gene, on the basis of its homology to another tyrosine phosphatase, the recently isolated human DEP-1/HPTP eta, has been named r-PTP eta. In rat thyroid cells the r-PTP eta gene acts as a differentiation marker, Indeed, the block of thyroid cell differentiation induced by viral and cellular oncogenes is associated with the inhibition or marked reduction of the expression of this gene and its expression is positively regulated by thyrotropin, the physiological stimulator of thyroid cell growth. (C) 1997 Academic Press.
Thyroid cell transformation inhibits the expression of a novel rat protein tyrosine phosphatase / Zhang, L; Martelli, Ml; Battaglia, C; Trapasso, Serena; Tramontano, Donatella; Viglietto, G; Porcellini, Antonio; Santoro, Massimo; Fusco, Alfredo. - In: EXPERIMENTAL CELL RESEARCH. - ISSN 0014-4827. - STAMPA. - 235:(1997), pp. 62-70. [10.1006/excr.1997.3659]
Thyroid cell transformation inhibits the expression of a novel rat protein tyrosine phosphatase.
TRAPASSO, SERENA;TRAMONTANO, DONATELLA;VIGLIETTO G;PORCELLINI, ANTONIOInvestigation
;SANTORO Massimo;FUSCO, ALFREDO
1997
Abstract
We have isolated a rat thyroid cDNA encoding a novel rat receptor-type tyrosine phosphatase protein. This gene, on the basis of its homology to another tyrosine phosphatase, the recently isolated human DEP-1/HPTP eta, has been named r-PTP eta. In rat thyroid cells the r-PTP eta gene acts as a differentiation marker, Indeed, the block of thyroid cell differentiation induced by viral and cellular oncogenes is associated with the inhibition or marked reduction of the expression of this gene and its expression is positively regulated by thyrotropin, the physiological stimulator of thyroid cell growth. (C) 1997 Academic Press.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
