The finding of new PXR modulators as potential leads for treatment of human disorders characterized by dysregulation of innate immunity and with inflammation is of wide interest. In this paper, we report the identification of the first example of natural marine PXR agonists, solomonsterols A and B, from a Theonella swinhoei sponge. The structures were determined by interpretation of NMR and ESIMS data, and the putative binding mode to PXR has been obtained through docking calculations.
Solomonsterols A and B from Theonella swinhoei. The first example of C-24 and C-23 sulfated sterols from a marine source endowed with a PXR agonistic activity / Festa, Carmen; De Marino, S.; D'Auria, M. V.; Bifulco, G.; Renga, B.; Fiorucci, S.; Petek, S.; Zampella, A.. - In: JOURNAL OF MEDICINAL CHEMISTRY. - ISSN 0022-2623. - 54:1(2011), pp. 401-405. [10.1021/jm100968b]
Solomonsterols A and B from Theonella swinhoei. The first example of C-24 and C-23 sulfated sterols from a marine source endowed with a PXR agonistic activity
Festa Carmen;De Marino S.;D'Auria M. V.;Zampella A.
2011
Abstract
The finding of new PXR modulators as potential leads for treatment of human disorders characterized by dysregulation of innate immunity and with inflammation is of wide interest. In this paper, we report the identification of the first example of natural marine PXR agonists, solomonsterols A and B, from a Theonella swinhoei sponge. The structures were determined by interpretation of NMR and ESIMS data, and the putative binding mode to PXR has been obtained through docking calculations.| File | Dimensione | Formato | |
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J. Med. Chem., 2011, 54, 401-405.pdf
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