Pinolidoxin, A Phytotoxic Nonenolide From Ascochyta-pinodes

Ascochyta pinodes, the causal agent of pea anthracnose, cultured on sterilized wheat, produces toxic metabolites. The main phytotoxin, named pinolidoxin, was isolated and characterized using spectral and chemical methods as 2-(2,4-hexadienoyloxy)-7,8-dihydroxy-9-propyl-5-nonen-9-olide, a new phytotoxic 10-macrolide. When assayed on host (pea) and non-host (bean) plants, pinolidoxin was highly toxic; towards brine shrimps it was only weakly toxic.