The influence of various psychoactive agents with different pharmacological effects on in vitro indoleamine N-methyltransferase activity is reported. The drugs having a marked anxiolytic activity were found to be inhibitors of the enzyme. Further, lorazepam and diazepam showed an inhibitory effect of the competitive type with respect to S-adenosylmethionine toward two additional biogenic amine transmethylases, histamine N-, and catechol o-methyltransferase
The Invitro Inhibition of Indoleamine N-methyltransferase By Antipsychotic-drugs and Benzodiazepines / Porta, Raffaele; M., Camardella; A., Verruti; P., Denegri; L., Miele; G., DELLA PIETRA. - In: RESEARCH COMMUNICATIONS IN PSYCHOLOGY PSYCHIATRY AND BEHAVIOR. - ISSN 0362-2428. - STAMPA. - 5:(1980), pp. 177-184.
The Invitro Inhibition of Indoleamine N-methyltransferase By Antipsychotic-drugs and Benzodiazepines
PORTA, RAFFAELE;
1980
Abstract
The influence of various psychoactive agents with different pharmacological effects on in vitro indoleamine N-methyltransferase activity is reported. The drugs having a marked anxiolytic activity were found to be inhibitors of the enzyme. Further, lorazepam and diazepam showed an inhibitory effect of the competitive type with respect to S-adenosylmethionine toward two additional biogenic amine transmethylases, histamine N-, and catechol o-methyltransferaseI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
