N-Acetyl-1,3-thiazolidine derivatives of cyclohexanones, when treated with a threefold excess N-bromosuccinimide in anhydrous chloroform at room temperature, smoothly afford N-acetyl-2,3-dihydro-1,4-benzothiazines. This represents the first general route to such heterocyclic system in one step from aliphatic precursors. The synthesis of optically active N-acetyl-2,3-dihydro-1,4-benzothiazines is also reported
A one-step synthesis of 2,3-dihydro-1,4-benzothiazines and phenothiazines from 1,3-thiazolidine derivatives of cyclohexanones R. Caputo; C. Ferreri; L. Longobardo; D. Mastroianni; G. Palumbo; S. Pedatella / Caputo, R.; Ferreri, C.; Longobardo, L.; Mastroianni, D.; Palumbo, Giovanni; Pedatella, S.. - In: HETEROCYCLES. - ISSN 0385-5414. - STAMPA. - 36:7(1993), pp. 1641-1644. [10.3987/COM-93-6379]
A one-step synthesis of 2,3-dihydro-1,4-benzothiazines and phenothiazines from 1,3-thiazolidine derivatives of cyclohexanones R. Caputo; C. Ferreri; L. Longobardo; D. Mastroianni; G. Palumbo; S. Pedatella
L. Longobardo;PALUMBO, GIOVANNI;
1993
Abstract
N-Acetyl-1,3-thiazolidine derivatives of cyclohexanones, when treated with a threefold excess N-bromosuccinimide in anhydrous chloroform at room temperature, smoothly afford N-acetyl-2,3-dihydro-1,4-benzothiazines. This represents the first general route to such heterocyclic system in one step from aliphatic precursors. The synthesis of optically active N-acetyl-2,3-dihydro-1,4-benzothiazines is also reportedI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
