The interactions between a few representative gold-based drugs and hen egg white lysozyme were studied by X-ray crystallography. High resolution crystal structures solved for three metallodrug-protein adducts provide valuable insight into the molecular mechanism of these promising metal compounds and the inherent protein metalation processes.
The mode of action of anticancer gold-based drugs: a structural perspective / Messori, L; Scaletti, F; Massai, L; Cinellu, Ma; Gabbiani, C; Vergara, Alessandro; Merlino, Antonello. - In: CHEMICAL COMMUNICATIONS. - ISSN 1359-7345. - 49:86(2013), pp. 10100-10102. [10.1039/c3cc46400h]
The mode of action of anticancer gold-based drugs: a structural perspective
VERGARA, ALESSANDRO;MERLINO, ANTONELLO
2013
Abstract
The interactions between a few representative gold-based drugs and hen egg white lysozyme were studied by X-ray crystallography. High resolution crystal structures solved for three metallodrug-protein adducts provide valuable insight into the molecular mechanism of these promising metal compounds and the inherent protein metalation processes.File in questo prodotto:
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