Our study was undertaken in order to evaluate hemodynamic effects of intravenous administration of Reproterol in patients with chronic obstructive lung disease (COLD). Reproterol is a monomulecolar combination of catecholamine and theophilline. Diastolic pulmonary pressure and wedge pressure decreased 20 minutes after Reproterol while total pulmonary resistances were reduced 10 minutes after drug administration; sistolic pulmonary pressure and cardiac index increased only after 10 minutes; heart rate increased until 15th minute. Reproterol, as a catecholamine-theophylline combination, has an additional site of action over and above the pure catecholamine effect owing to inhibition of phosphodiesterase; so an increase in cAMP content is achieved either by increasing the synthesis or by blocking the breakdown. Our results assess that Reproterol has a beneficial effect on pulmonary hemodynamics in COLD.
The hemodynamic effects of reproterol in patients with chronic obstructive lung disease [EFFETTI EMODINAMICI DEL REPROTEROLO IN SOGGETTI AFFETTI DA BRONCOPNEUMOPATIA CRONICA OSTRUTTIVA] / Bonaduce, D.; Ferrara, Nicola; Canonico, V.; Cocozza, M.; Petretta, Mario; Romano, E.; Rengo, F.. - In: GIORNALE ITALIANO DI CARDIOLOGIA. - ISSN 0046-5968. - 11:(1981), pp. 1467-1471.
The hemodynamic effects of reproterol in patients with chronic obstructive lung disease [EFFETTI EMODINAMICI DEL REPROTEROLO IN SOGGETTI AFFETTI DA BRONCOPNEUMOPATIA CRONICA OSTRUTTIVA]
FERRARA, NICOLA;PETRETTA, MARIO;
1981
Abstract
Our study was undertaken in order to evaluate hemodynamic effects of intravenous administration of Reproterol in patients with chronic obstructive lung disease (COLD). Reproterol is a monomulecolar combination of catecholamine and theophilline. Diastolic pulmonary pressure and wedge pressure decreased 20 minutes after Reproterol while total pulmonary resistances were reduced 10 minutes after drug administration; sistolic pulmonary pressure and cardiac index increased only after 10 minutes; heart rate increased until 15th minute. Reproterol, as a catecholamine-theophylline combination, has an additional site of action over and above the pure catecholamine effect owing to inhibition of phosphodiesterase; so an increase in cAMP content is achieved either by increasing the synthesis or by blocking the breakdown. Our results assess that Reproterol has a beneficial effect on pulmonary hemodynamics in COLD.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
