The aim of this mini-review is to draw together the main concepts and findings that have emerged from recent studies of the cardiac channel protein Nav1.5. This complex protein is encoded by the SCN5A gene that, in its mutated form, is implicated in various diseases, particularly channelopathies, specifically at cardiac tissue level. Here we describe the structural, and functional aspects of Nav1.5 including post-translational modifications in normal conditions, and the main human channelopathies in which this protein may be the cause or trigger. Lastly, we also briefly discuss interacting proteins that are relevant for these channel functions in normal and disease conditions.

The multi-faceted aspects of the complex cardiac Nav1.5 protein in membrane function and pathophysiology / Detta, Nicola; Frisso, Giulia; Salvatore, Francesco. - In: BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS. - ISSN 1570-9639. - 1854:10 Pt A(2015), pp. 1502-1509. [10.1016/j.bbapap.2015.07.009]

The multi-faceted aspects of the complex cardiac Nav1.5 protein in membrane function and pathophysiology

DETTA, NICOLA;FRISSO, GIULIA;SALVATORE, FRANCESCO
2015

Abstract

The aim of this mini-review is to draw together the main concepts and findings that have emerged from recent studies of the cardiac channel protein Nav1.5. This complex protein is encoded by the SCN5A gene that, in its mutated form, is implicated in various diseases, particularly channelopathies, specifically at cardiac tissue level. Here we describe the structural, and functional aspects of Nav1.5 including post-translational modifications in normal conditions, and the main human channelopathies in which this protein may be the cause or trigger. Lastly, we also briefly discuss interacting proteins that are relevant for these channel functions in normal and disease conditions.
2015
The multi-faceted aspects of the complex cardiac Nav1.5 protein in membrane function and pathophysiology / Detta, Nicola; Frisso, Giulia; Salvatore, Francesco. - In: BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS. - ISSN 1570-9639. - 1854:10 Pt A(2015), pp. 1502-1509. [10.1016/j.bbapap.2015.07.009]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/613229
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