Growth hormone (GH)/insulin-like growth factor 1 (IGF-1) axis abnormalities in multiple sclerosis (MS) suggest their role in its pathogenesis. Interferon β (IFN-β) efficacy could be mediated also by an increase of IGF-1 levels. A 2-year longitudinal study was performed to estimate the prevalence of GH and/or IGF-1 deficiency in clinically isolated syndrome (CIS) patients and their correlation with conversion to MS in IFN treated patients.
Growth hormone/IGF-1 axis longitudinal evaluation in clinically isolated syndrome patients on interferon β-1b therapy: stimulation tests and correlations with clinical and radiological conversion to multiple sclerosis / Lanzillo, Roberta; Di Somma, C; Quarantelli, M; Carotenuto, A; Pivonello, Claudia; Moccia, M; Cianflone, A; Marsili, A; Puorro, G; Sacca', Francesco; Russo, C. V; De Luca Picione, C; Ausiello, F; Colao, Annamaria; BRESCIA MORRA, Vincenzo. - In: EUROPEAN JOURNAL OF NEUROLOGY. - ISSN 1351-5101. - 24:2(2017), pp. 446-449-449. [10.1111/ene.13207]
Growth hormone/IGF-1 axis longitudinal evaluation in clinically isolated syndrome patients on interferon β-1b therapy: stimulation tests and correlations with clinical and radiological conversion to multiple sclerosis
LANZILLO, ROBERTA;Carotenuto, A;PIVONELLO, CLAUDIA;Moccia, M;SACCA', FRANCESCO;Russo, C. V;COLAO, ANNAMARIA;BRESCIA MORRA, VINCENZO
2017
Abstract
Growth hormone (GH)/insulin-like growth factor 1 (IGF-1) axis abnormalities in multiple sclerosis (MS) suggest their role in its pathogenesis. Interferon β (IFN-β) efficacy could be mediated also by an increase of IGF-1 levels. A 2-year longitudinal study was performed to estimate the prevalence of GH and/or IGF-1 deficiency in clinically isolated syndrome (CIS) patients and their correlation with conversion to MS in IFN treated patients.| File | Dimensione | Formato | |
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