The morpho-functional principles of secretory traffic are still unclear, in stark contrast with our advanced knowledge of the underlying molecular machineries. Recently, the conceptual and technological hindrances that have delayed progress in this area have been disappearing, and new glimpses of the organization of traffic in intact cells are being revealed by a cluster of powerful morphological techniques. Here, we discuss the new advances in the light of the three main possible traffic principles: by anterograde vesicles, progression/maturation, and flow via continuities.
The morpho-functional organization of secretory traffic. Here today, where tomorrow? / Luini, Alberto; Mironov, Alexander A; DE MATTEIS, Maria Antonietta; Griffiths, Gareth. - In: MEDICINA NEI SECOLI. - ISSN 0394-9001. - 19:1(2007), p. 29-54.
The morpho-functional organization of secretory traffic. Here today, where tomorrow?
DE MATTEIS, Maria Antonietta;
2007
Abstract
The morpho-functional principles of secretory traffic are still unclear, in stark contrast with our advanced knowledge of the underlying molecular machineries. Recently, the conceptual and technological hindrances that have delayed progress in this area have been disappearing, and new glimpses of the organization of traffic in intact cells are being revealed by a cluster of powerful morphological techniques. Here, we discuss the new advances in the light of the three main possible traffic principles: by anterograde vesicles, progression/maturation, and flow via continuities.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
