DNA methylome analysis identifies accelerated epigenetic ageing associated with postmenopausal breast cancer susceptibility

Ambatipudi, Srikant; Horvath, Steve; Perrier, Flavie; Cuenin, Cyrille; Hernandez Vargas, Hector; Le Calvez Kelm, Florence; Durand, Geoffroy; Byrnes, Graham; Ferrari, Pietro; Bouaoun, Liacine; Sklias, Athena; Chajes, Véronique; Overvad, Kim; Severi, Gianluca; Baglietto, Laura; Clavel Chapelon, Françoise; Kaaks, Rudolf; Barrdahl, Myrto; Boeing, Heiner; Trichopoulou, Antonia; Lagiou, Pagona; Naska, Androniki; Masala, Giovanna; Agnoli, Claudia; Polidoro, Silvia; Tumino, Rosario; Panico, Salvatore; Dollé, Martijn; Peeters, Petra H. M; Onland Moret, N. Charlotte; Sandanger, Torkjel M; Nøst, Therese H; Weiderpass, Elisabete; Quirós, J. Ramón; Agudo, Antonio; Rodriguez Barranco, Miguel; Huerta Castaño, José María; Barricarte, Aurelio; Fernández, Ander Matheu; Travis, Ruth C; Vineis, Paolo; Muller, David C; Riboli, Elio; Gunter, Marc; Romieu, Isabelle; Herceg, Zdenko

doi:10.1016/j.ejca.2017.01.014

A vast majority of human malignancies are associated with ageing, and age is a strong predictor of cancer risk. Recently, DNA methylation-based marker of ageing, known as 'epigenetic clock', has been linked with cancer risk factors. This study aimed to evaluate whether the epigenetic clock is associated with breast cancer risk susceptibility and to identify potential epigenetics-based biomarkers for risk stratification.

DNA methylome analysis identifies accelerated epigenetic ageing associated with postmenopausal breast cancer susceptibility / Ambatipudi, Srikant; Horvath, Steve; Perrier, Flavie; Cuenin, Cyrille; Hernandez Vargas, Hector; Le Calvez Kelm, Florence; Durand, Geoffroy; Byrnes, Graham; Ferrari, Pietro; Bouaoun, Liacine; Sklias, Athena; Chajes, Véronique; Overvad, Kim; Severi, Gianluca; Baglietto, Laura; Clavel Chapelon, Françoise; Kaaks, Rudolf; Barrdahl, Myrto; Boeing, Heiner; Trichopoulou, Antonia; Lagiou, Pagona; Naska, Androniki; Masala, Giovanna; Agnoli, Claudia; Polidoro, Silvia; Tumino, Rosario; Panico, Salvatore; Dollé, Martijn; Peeters, Petra H. M; Onland Moret, N. Charlotte; Sandanger, Torkjel M; Nøst, Therese H; Weiderpass, Elisabete; Quirós, J. Ramón; Agudo, Antonio; Rodriguez Barranco, Miguel; Huerta Castaño, José María; Barricarte, Aurelio; Fernández, Ander Matheu; Travis, Ruth C; Vineis, Paolo; Muller, David C; Riboli, Elio; Gunter, Marc; Romieu, Isabelle; Herceg, Zdenko. - In: EUROPEAN JOURNAL OF CANCER. - ISSN 1879-0852. - 75:(2017), p. 299-307. [10.1016/j.ejca.2017.01.014]