Peptide based vaccines may suffer from limited stability and inefficient delivery to professional antigen-presenting cells (APCs), such as dendritic cells (DCs). In order to overcome such limitations, several types of biodegradable nanoparticles (NPs) have been developed as carrier system for antigens. The present study describes for the first time the extensive biological characterization of cationic NPs made of poly (D,L-lactide-co-glycolide) (PLGA) and polyethylenimine (PLGA/PEI) as delivery system for protein/peptide antigens, with potential in therapeutic cancer vaccine development.
Functional characterization of biodegradable nanoparticles as antigen delivery system / Petrizzo, A; Conte, Claudia; Tagliamonte, M; Napolitano, M; Bifulco, K; Carriero, V; De Stradis, A; Tornesello, M. L; Buonaguro, F. M; Quaglia, Fabiana; Buonaguro, L.. - In: JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH. - ISSN 1756-9966. - 34:1(2015), p. 114. [10.1186/s13046-015-0231-9]
Functional characterization of biodegradable nanoparticles as antigen delivery system
CONTE, CLAUDIA;QUAGLIA, FABIANA;
2015
Abstract
Peptide based vaccines may suffer from limited stability and inefficient delivery to professional antigen-presenting cells (APCs), such as dendritic cells (DCs). In order to overcome such limitations, several types of biodegradable nanoparticles (NPs) have been developed as carrier system for antigens. The present study describes for the first time the extensive biological characterization of cationic NPs made of poly (D,L-lactide-co-glycolide) (PLGA) and polyethylenimine (PLGA/PEI) as delivery system for protein/peptide antigens, with potential in therapeutic cancer vaccine development.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
