The different presentation of adrenocortical tumors in benign adenoma (ACA) or adrenocortical carcinoma (ACC) is related to the variability at the molecular level. The insulin-like growth factor (IGF) system is one of the most frequently altered pathways in ACC. In this review we will critically analyze the evidence regarding the pathogenic role of the IGF system in adrenal tumorigenesis, focusing on ACC. We will also examine the pre-clinical and clinical studies which investigated the targeting of the IGF system as a therapeutic approach in ACC.
The role of Insulin-like Growth Factor (IGF) system in the adrenocortical tumors / Altieri, Barbara; Colao, Annamaria; Faggiano, Antongiulio. - In: MINERVA ENDOCRINOLOGICA. - ISSN 0391-1977. - 44:(2019), pp. 43-57. [10.23736/S0391-1977.18.02882-1]
The role of Insulin-like Growth Factor (IGF) system in the adrenocortical tumors
Colao, Annamaria;Faggiano, Antongiulio
2019
Abstract
The different presentation of adrenocortical tumors in benign adenoma (ACA) or adrenocortical carcinoma (ACC) is related to the variability at the molecular level. The insulin-like growth factor (IGF) system is one of the most frequently altered pathways in ACC. In this review we will critically analyze the evidence regarding the pathogenic role of the IGF system in adrenal tumorigenesis, focusing on ACC. We will also examine the pre-clinical and clinical studies which investigated the targeting of the IGF system as a therapeutic approach in ACC.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
