Background. Breast attenuation may impact the diagnostic accuracy of stress myocardial perfusion imaging (MPI) with single-photon emission computed tomography (SPECT). We compared the performance of conventional (C)-SPECT and cadmium-zinc-telluride (CZT)-SPECT systems in women with low-intermediate likelihood of coronary artery disease (CAD). Methods and Results. A total of 109 consecutive women underwent stress-optional rest MPI by both C-SPECT and CZT-SPECT. In the overall study population, a weak albeit significant correlation between total perfusion defect (TPD) measured by C-SPECT and CZT-SPECT was observed (r = 0.38, P < .001) and at Bland-Altman analysis the mean difference in TPD (C-SPECT minus CZT-SPECT) was 2.40% (P < .001). Overall concordance of semiquantitative diagnostic performance between C-SPECT and CZT-SPECT was observed in 52 (48%) women with a κ value of 0.09. Normalcy rate was significantly higher using CZT-SPECT compared to C-SPECT (P < .001). Machine learning analysis performed through the implementation of J48 algorithm proved that CZT-SPECT has higher sensitivity, specificity, and accuracy than C-SPECT. Conclusions. In women with low-intermediate likelihood of CAD, there is a poor concordance of diagnostic performance between C-SPECT and CZT-SPECT and CZT-SPECT allows better normalcy rate detection compared to C-SPECT.

Head-to-head comparison of diagnostic accuracy of stress-only myocardial perfusion imaging with conventional and cadmium-zinc telluride single-photon emission computed tomography in women with suspected coronary artery disease / Mannarino, Teresa; Assante, Roberta; Ricciardi, Carlo; Zampella, Emilia; Nappi, Carmela; Gaudieri, Valeria; Mainolfi, Ciro Gabriele; Di Vaia, Eugenio; Petretta, Mario; Cesarelli, Mario; Cuocolo, Alberto; Acampa, Wanda. - In: JOURNAL OF NUCLEAR CARDIOLOGY. - ISSN 1071-3581. - 28:3(2021), pp. 888-897. [10.1007/s12350-019-01789-7]

Head-to-head comparison of diagnostic accuracy of stress-only myocardial perfusion imaging with conventional and cadmium-zinc telluride single-photon emission computed tomography in women with suspected coronary artery disease

Mannarino, Teresa
Primo
;
Assante, Roberta;RICCIARDI, CARLO;Zampella, Emilia;Nappi, Carmela;Gaudieri, Valeria;Mainolfi, Ciro Gabriele;Di Vaia, Eugenio;Petretta, Mario;Cesarelli, Mario;Cuocolo, Alberto;Acampa, Wanda
Ultimo
2021

Abstract

Background. Breast attenuation may impact the diagnostic accuracy of stress myocardial perfusion imaging (MPI) with single-photon emission computed tomography (SPECT). We compared the performance of conventional (C)-SPECT and cadmium-zinc-telluride (CZT)-SPECT systems in women with low-intermediate likelihood of coronary artery disease (CAD). Methods and Results. A total of 109 consecutive women underwent stress-optional rest MPI by both C-SPECT and CZT-SPECT. In the overall study population, a weak albeit significant correlation between total perfusion defect (TPD) measured by C-SPECT and CZT-SPECT was observed (r = 0.38, P < .001) and at Bland-Altman analysis the mean difference in TPD (C-SPECT minus CZT-SPECT) was 2.40% (P < .001). Overall concordance of semiquantitative diagnostic performance between C-SPECT and CZT-SPECT was observed in 52 (48%) women with a κ value of 0.09. Normalcy rate was significantly higher using CZT-SPECT compared to C-SPECT (P < .001). Machine learning analysis performed through the implementation of J48 algorithm proved that CZT-SPECT has higher sensitivity, specificity, and accuracy than C-SPECT. Conclusions. In women with low-intermediate likelihood of CAD, there is a poor concordance of diagnostic performance between C-SPECT and CZT-SPECT and CZT-SPECT allows better normalcy rate detection compared to C-SPECT.
2021
Head-to-head comparison of diagnostic accuracy of stress-only myocardial perfusion imaging with conventional and cadmium-zinc telluride single-photon emission computed tomography in women with suspected coronary artery disease / Mannarino, Teresa; Assante, Roberta; Ricciardi, Carlo; Zampella, Emilia; Nappi, Carmela; Gaudieri, Valeria; Mainolfi, Ciro Gabriele; Di Vaia, Eugenio; Petretta, Mario; Cesarelli, Mario; Cuocolo, Alberto; Acampa, Wanda. - In: JOURNAL OF NUCLEAR CARDIOLOGY. - ISSN 1071-3581. - 28:3(2021), pp. 888-897. [10.1007/s12350-019-01789-7]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/754617
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