G protein-coupled receptors (GPCRs) represent the largest family of druggable targets in human genome. Although several GPCRs can cross-talk with the human epidermal growth factor receptors (HERs), the expression and function of most GPCRs remain unknown in HER2+ breast cancer (BC). In this study, we aimed to evaluate gene expression of GPCRs in tumorigenic or anti-HER2 drug-resistant cells and to understand the potential role of candidate GPCRs in HER2+ BC.

GPCRs profiling and identification of GPR110 as a potential new target in HER2+ breast cancer / Bhat, R. R.; Yadav, P.; Sahay, D.; Bhargava, D. K.; Creighton, C. J.; Yazdanfard, S.; Al-rawi, A.; Yadav, V.; Qin, L.; Nanda, S.; Sethunath, V.; Fu, X.; De Angelis, C.; Narkar, V. A.; Osborne, C. K.; Schiff, R.; Trivedi, M. V.. - In: BREAST CANCER RESEARCH AND TREATMENT. - ISSN 0167-6806. - 170:2(2018), pp. 279-292. [10.1007/s10549-018-4751-9]

GPCRs profiling and identification of GPR110 as a potential new target in HER2+ breast cancer

De Angelis C.;
2018

Abstract

G protein-coupled receptors (GPCRs) represent the largest family of druggable targets in human genome. Although several GPCRs can cross-talk with the human epidermal growth factor receptors (HERs), the expression and function of most GPCRs remain unknown in HER2+ breast cancer (BC). In this study, we aimed to evaluate gene expression of GPCRs in tumorigenic or anti-HER2 drug-resistant cells and to understand the potential role of candidate GPCRs in HER2+ BC.
2018
GPCRs profiling and identification of GPR110 as a potential new target in HER2+ breast cancer / Bhat, R. R.; Yadav, P.; Sahay, D.; Bhargava, D. K.; Creighton, C. J.; Yazdanfard, S.; Al-rawi, A.; Yadav, V.; Qin, L.; Nanda, S.; Sethunath, V.; Fu, X.; De Angelis, C.; Narkar, V. A.; Osborne, C. K.; Schiff, R.; Trivedi, M. V.. - In: BREAST CANCER RESEARCH AND TREATMENT. - ISSN 0167-6806. - 170:2(2018), pp. 279-292. [10.1007/s10549-018-4751-9]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/776667
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