Long-term efficacy and safety of eculizumab in Japanese patients with generalized myasthenia gravis: A subgroup analysis of the REGAIN open-label extension study

Murai, H.; Uzawa, A.; Suzuki, Y.; Imai, T.; Shiraishi, H.; Suzuki, H.; Okumura, M.; O'Brien, F.; Wang, J. -J.; Fujita, K. P.; Utsugisawa, K.; Claudio Gabriel Mazia 11,; Miguel Wilken 11,; Fabio Barroso 11,; Juliet Saba 11,; Marcelo Rugiero 12,; Mariela Bettini 12,; Marcelo Chaves 12,; Gonzalo Vidal 12,; Alejandra Dalila Garcia 12,; Jan De Bleecker 13,; Guy Van den Abeele 13,; Kathy de Koning 13,; Katrien De Mey 13,; Rudy Mercelis 14,; Délphine Mahieu 14,; Linda Wagemaekers 14,; Philip Van Damme 15,; Annelies Depreitere 16,; Caroline Schotte 16,; Charlotte Smetcoren 16,; Olivier Stevens 16,; Sien Van Daele 16,; Nicolas Vandenbussche 16,; Annelies Vanhee 16,; Sarah Verjans 16,; Jan Vynckier 16,; Ann D'Hondt 16,; Petra Tilkin 16,; Alzira Alves de Siqueira Carvalho 17,; Igor Dias Brockhausen 17,; David Feder 17,; Daniel Ambrosio 17,; Pamela César 17,; Ana Paula Melo 17,; Renata Martins Ribeiro 17,; Rosana Rocha 17,; Bruno Bezerra Rosa 17,; Thabata Veiga 17,; Luiz Augusto da Silva 17,; Murilo Santos Engel 17,; Jordana Gonçalves Geraldo 17,; Maria da Penha Ananias Morita 18,; Erica Nogueira Coelho 18,; Gabriel Paiva 18,; Marina Pozo 18,; Natalia Prando 18,; Debora Dada Martineli Torres 18,; Cristiani Fernanda Butinhao 18,; Gustavo Duran 18,; Tamires Cristina Gomes da Silva 18,; Luiz Otavio Maia Gonçalves 18,; Lucas Eduardo Pazetto 18,; Tomás Augusto Suriane Fialho 18,; Luciana Renata Cubas Volpe 18,; Luciana Souza Duca 18,; Acary Souza Bulle Oliveira 19,; Ana Carolina Amaral Andrade 19,; Marcelo Annes 19,; Liene Duarte Silva 19,; Valeria Cavalcante Lino 19,; Wladimir Pinto 19,; Natália Assis 19,; Fernanda Carrara 19,; Carolina Miranda 19,; Iandra Souza 19,; Patricia Fernandes 19,; Zaeem Siddiqi 20,; Cecile Phan 20,; Jeffrey Narayan 20,; Derrick Blackmore 20,; Ashley Mallon 20,; Rikki Roderus 20,; Elizabeth Watt 20,; Jana Junkerova 21,; Barbora Kurkova 21,; Katarina Reguliova 21,; Olga Zapletalova 21,; Jiri Pitha 22,; Iveta Novakova 22,; Michaela Tyblova 22,; Ivana Jurajdova 22,; Marcela Wolfova 22,; Henning Andersen 23,; Thomas Harbo 23,; Lotte Vinge 23,; Susanne Krogh 23,; Anita Mogensen 23,; John Vissing 24,; Joan Højgaard 24,; Nanna Witting 24,; Anne Mette Ostergaard Autzen 24,; Jane Pedersen 24,; Juha-Pekka Eralinna 25,; Mikko Laaksonen 25,; Olli Oksaranta 25,; Tuula Harrison 25,; Jaana Eriksson 25,; Csilla Rozsa 26,; Melinda Horvath 26,; Gabor Lovas 26,; Judit Matolcsi 26,; Gyorgyi Szabo 26,; Gedeonne Jakab 26,; Brigitta Szabadosne 26,; Giovanni Antonini 27,; Antonella Di Pasquale 27,; Matteo Garibaldi 27,; Stefania Morino 27,; Fernanda Troili 27,; Laura Fionda 27,; Filla, Allessandro; Costabile, Teresa; Marano, Enrico; Saccà, Francesco; Fasanaro, Angiola; Marsili, Angela; Puorro, Giorgia; Renato Mantegazza 29,; Carlo Antozzi 29,; Silvia Bonanno 29,; Giorgia Camera 29,; Alberta Locatelli 29,; Lorenzo Maggi 29,; Maria Pasanisi 29,; Angela Campanella 29,; Amelia Evoli 30,; Paolo Emilio Alboini 30,; Valentina D'Amato 30,; Raffaele Iorio 30,; Tetsuya Kanai 31,; Naoki Kawaguchi 31,; Masahiro Mori 31,; Yoko Kaneko 31,; Akiko Kanzaki 31,; Eri Kobayashi 31,; Katsuhisa Masaki 32,; Dai Matsuse 32,; Takuya Matsushita 32,; Taira Uehara 32,; Misa Shimpo 32,; Maki Jingu 32,; Keiko Kikutake 32,; Yumiko Nakamura 32,; Yoshiko Sano 32,; Yuriko Nagane 33,; Ikuko Kamegamori 33,; Tomoko Tsuda 33,; Yuko Fujii 33,; Kazumi Futono 33,; Yukiko Ozawa 33,; Aya Mizugami 33,; Yuka Saito 33,; Miyuki Morikawa 34,; Makoto Samukawa 34,; Sachiko Kamakura 34,; Eriko Miyawaki 34,; Teiichiro Mitazaki 35,; Masakatsu Motomura 35,; Akihiro Mukaino 35,; Shunsuke Yoshimura 35,; Shizuka Asada 35,; Seiko Yoshida 35,; Shoko Amamoto 35,; Tomomi Kobashikawa 35,; Megumi Koga 35,; Yasuko Maeda 35,; Kazumi Takada 35,; Mihoko Takada 35,; Masako Tsurumaru 35,; Yumi Yamashita 35,; Tetsuya Akiyama 36,; Koichi Narikawa 36,; Ohito Tano 36,; Kenichi Tsukita 36,; Rikako Kurihara 36,; Fumie Meguro 36,; Yusuke Fukuda 36,; Miwako Sato 36,; Soichiro Funaka 37,; Tomohiro Kawamura 37,; Masayuki Makamori 37,; Masanori Takahashi 37,; Namie Taichi 37,; Tomoya Hasuike 37,; Eriko Higuchi 37,; Hisako Kobayashi 37,; Kaori Osakada 37,; Emiko Tsuda 38,; Shun Shimohama 38,; Takashi Hayashi 38,; Shin Hisahara 38,; Jun Kawamata 38,; Takashi Murahara 38,; Masaki Saitoh 38,; Shuichiro Suzuki 38,; Daisuke Yamamoto 38,; Yoko Ishiyama 38,; Naoko Ishiyama 38,; Mayuko Noshiro 38,; Rumi Takeyama 38,; Kaori Uwasa 38,; Ikuko Yasuda 38,; Anneke van der Kooi 39,; Marianne de Visser 39,; Tamar Gibson 39,; Carlos Casasnovas 40,; Maria Antonia Alberti Aguilo 40,; Christian Homedes-Pedret 40,; Natalia Julia Palacios 40,; Laura Diez Porras 40,; Valentina Velez Santamaria 40,; Ana Lazaro 40,; Exuperio Diez Tejedor 41,; Pilar Gomez Salcedo 41,; Mireya Fernandez-Fournier 41,; Pedro Lopez Ruiz 41,; Francisco Javier Rodriguez de Rivera 41,; Maria Sastre 41,; Josep Gamez 42,; Pilar Sune 42,; Maria Salvado 42,; Gisela Gili 42,; Gonzalo Mazuela 42,; Isabel Illa 43,; Elena Cortes Vicente 43,; Jordi Diaz-Manera 43,; Luis Antonio Querol Gutierrez 43,; Ricardo Rojas Garcia 43,; Nuria Vidal 43,; Elisabet Arribas-Ibar 43,; Fredrik Piehl 44,; Albert Hietala 44,; Lena Bjarbo 44,; Ihsan Sengun 45,; Arzu Meherremova 45,; Pinar Ozcelik 45,; Bengu Balkan 45,; Celal Tuga 45,; Muzeyyen Ugur 45,; Sevim Erdem-Ozdamar 46,; Can Ebru Bekircan-Kurt 46,; Nazire Pinar Acar 46,; Ezgi Yilmaz 46,; Yagmur Caliskan 46,; Gulsah Orsel 46,; Husnu Efendi 47,; Seda Aydinlik 47,; Hakan Cavus 47,; Ayse Kutlu 47,; Gulsah Becerikli 47,; Cansu Semiz 47,; Ozlem Tun 47,; Murat Terzi 48,; Baki Dogan 48,; Musa Kazim Onar 48,; Sedat Sen 48,; Tugce Kirbas Cavdar 48,; Adife Veske 48,; Fiona Norwood 49,; Aikaterini Dimitriou 49,; Jakit Gollogly 49,; Mohamed Mahdi-Rogers 49,; Arshira Seddigh 49,; Giannis Sokratous 49,; Gal Maier 49,; Faisal Sohail 49,; Saiju Jacob 50,; Girija Sadalage 50,; Pravin Torane 50,; Claire Brown 50,; Amna Shah 50,; Sivakumar Sathasivam 51,; Heike Arndt 51,; Debbie Davies 51,; Dave Watling 51,; Anthony Amato 52,; Thomas Cochrane 52,; Mohammed Salajegheh 52,; Kristen Roe 52,; Katherine Amato 52,; Shirli Toska 52,; Gil Wolfe 53,; Nicholas Silvestri 53,; Kara Patrick 53,; Karen Zakalik 53,; Jonathan Katz 54,; Robert Miller 54,; Marguerite Engel 54,; Dallas Forshew 54,; Elena Bravver 55,; Benjamin Brooks 55,; Sarah Plevka 55,; Maryanne Burdette 55,; Scott Cunningham 55,; Mohammad Sanjak 55,; Megan Kramer 55,; Joanne Nemeth 55,; Clara Schommer 55,; Scott Tierney 55,; Vern Juel 56,; Jeffrey Guptill 56,; Lisa Hobson-Webb 56,; Janice Massey 56,; Kate Beck 56,; Donna Carnes 56,; John Loor 56,; Amanda Anderson 56,; Robert Pascuzzi 57,; Cynthia Bodkin 57,; John Kincaid 57,; Riley Snook 57,; Sandra Guingrich 57,; Angela Micheels 57,; Vinay Chaudhry 58,; Andrea Corse 58,; Betsy Mosmiller 58,; Andrea Kelley 58,; Doreen Ho 59,; Jayashri Srinivasan 59,; Michal Vytopil 59,; Jordan Jara 59,; Nicholas Ventura 59,; Stephanie Scala 59,; Cynthia Carter 59,; Craig Donahue 59,; Carol Herbert 59,; Elaine Weiner 59,; Sharmeen Alam 59,; Jonathan McKinnon 60,; Laura Haar 60,; Naya McKinnon 60,; Karan Alcon 60,; Kaitlyn McKenna 60,; Nadia Sattar 60,; Kevin Daniels 60,; Dennis Jeffery 60,; Miriam Freimer 61,; Joseph Chad Hoyle 61,; John Kissel 61,; Julie Agriesti 61,; Sharon Chelnick 61,; Louisa Mezache 61,; Colleen Pineda 61,; Filiz Muharrem 61,; Chafic Karam 62,; Julie Khoury 62,; Tessa Marburger 62,; Harpreet Kaur 62,; Diana Dimitrova 62,; James Gilchrist 63,; Brajesh Agrawal 63,; Mona Elsayed 63,; Stephanie Kohlrus 63,; Angela Andoin 63,; Taylor Darnell 63,; Laura Golden 63,; Barbara Lokaitis 63,; Jenna Seelback 63,; Srikanth Muppidi 64,; Neelam Goyal 64,; Sarada Sakamuri 64,; Yuen, T So 64; Shirley Paulose 64,; Sabrina Pol 64,; Lesly Welsh 64,; Ratna Bhavaraju-Sanka 65,; Alejandro Tobon Gonzales 65,; Lorraine Dishman 65,; Floyd Jones 65,; Anna Gonzalez 65,; Patricia Padilla 65,; Amy Saklad 65,; Marcela Silva 65,; Mohamed Kazamel 66,; Mohammad Alsharabati 66,; Liang Lu 66,; Kenkichi Nozaki 66,; Sandi Mumfrey-Thomas 66,; Amy Woodall 66,; Tahseen Mozaffar 67,; Tiyonnoh Cash 67,; Namita Goyal 67,; Gulmohor Roy 67,; Veena Mathew 67,; Fatima Maqsood 67,; Brian Minton 67,; H James Jones 68,; Jeffrey Rosenfeld 68,; Rebekah Garcia 68,; Laura Echevarria 68,; Sonia Garcia 68,; Michael Pulley 69,; Shachie Aranke 69,; Alan Ross Berger 69,; Jaimin Shah 69,; Yasmeen Shabbir 69,; Lisa Smith 69,; Mary Varghese 69,; Laurie Gutmann 70,; Ludwig Gutmann 70,; Nivedita Jerath 70,; Christopher Nance 70,; Andrea Swenson 70,; Heena Olalde 70,; Nicole Kressin 70,; Jeri Sieren 70,; Richard Barohn 71,; Mazen Dimachkie 71,; Melanie Glenn 71,; April McVey 71,; Mamatha Pasnoor 71,; Jeffery Statland 71,; Yunxia Wang 71,; Tina Liu 71,; Kelley Emmons 71,; Nicole Jenci 71,; Jerry Locheke 71,; Alex Fondaw 71,; Kathryn Johns 71,; Gabrielle Rico 71,; Maureen Walsh 71,; Laura Herbelin 71,; Charlene Hafer-Macko 72,; Justin Kwan 72,; Lindsay Zilliox 72,; Karen Callison 72,; Valerie Young 72,; Beth DiSanzo 72,; Kerry Naunton 72,; Michael Benatar 73,; Martin Bilsker 73,; Khema Sharma 73,; Anne Cooley 73,; Eliana Reyes 73,; Sara-Claude Michon 73,; Danielle Sheldon 73,; Julie Steele 73,; James Howard Jr 74,; Chafic Karam 74,; Manisha Chopra 74,; Rebecca Traub 74,; Tuan Vu 75,; Lara Katzin 75,; Terry McClain 75,; Brittany Harvey 75,; Adam Hart 75,; Kristin Huynh 75,; Said Beydoun 76,; Amaiak Chilingaryan 76,; Victor Doan 76,; Brian Droker 76,; Hui Gong 76,; Sanaz Karimi 76,; Frank Lin 76,; Terry McClain 76,; Krishna Pokala 76,; Akshay Shah 76,; Anh Tran 76,; Salma Akhter 76,; Ali Malekniazi 76,; Rup Tandan 77,; Michael Hehir 77,; Waqar Waheed 77,; Shannon Lucy 77,; Michael Weiss 78,; Jane Distad 78,; Susan Strom 78,; Sharon Downing 78,; Bryan Kim 78,; Richard Nowak 79,; Daniel Dicapua 79,; Benison Keung 79,; Aditya Kumar 79,; Huned Patwa 79,; Kimberly Robeson 79,; Irene Yang 79,; Joan Nye 79,; Hong Vu, .

doi:10.1016/j.jns.2019.08.004

The terminal complement inhibitor eculizumab was shown to improve myasthenia gravis-related symptoms in the 26-week, phase 3, randomized, double-blind, placebo-controlled REGAIN study (NCT01997229). In this 52-week sub-analysis of the open-label extension of REGAIN (NCT02301624), eculizumab's efficacy and safety were assessed in 11 Japanese and 88 Caucasian patients with anti-acetylcholine receptor antibody-positive refractory generalized myasthenia gravis. For patients who had received placebo during REGAIN, treatment with open-label eculizumab resulted in generally similar outcomes in the Japanese and Caucasian populations. Rapid improvements were maintained for 52 weeks, assessed by change in score from open-label extension baseline to week 52 (mean [standard error]) using the following scales (in Japanese and Caucasian patients, respectively): Myasthenia Gravis Activities of Daily Living (−2.4 [1.34] and − 3.3 [0.65]); Quantitative Myasthenia Gravis (−2.9 [1.98] and − 4.3 [0.79]); Myasthenia Gravis Composite (−4.5 [2.63] and − 4.9 [1.19]); and Myasthenia Gravis Quality of Life 15-item questionnaire (−8.6 [5.68] and − 6.5 [1.93]). Overall, the safety of eculizumab was consistent with its known safety profile. In this interim sub-analysis, the efficacy and safety of eculizumab in Japanese and Caucasian patients were generally similar, and consistent with the overall REGAIN population.

Long-term efficacy and safety of eculizumab in Japanese patients with generalized myasthenia gravis: A subgroup analysis of the REGAIN open-label extension study / H., Murai; A., Uzawa; Y., Suzuki; T., Imai; H., Shiraishi; H., Suzuki; M., Okumura; F., O'Brien; J. -J., Wang; K. P., Fujita; K., Utsugisawa; Gabriel Mazia 11, Claudio; Wilken 11, Miguel; Barroso 11, Fabio; Saba 11, Juliet; Rugiero 12, Marcelo; Bettini 12, Mariela; Chaves 12, Marcelo; Vidal 12, Gonzalo; Dalila Garcia 12, Alejandra; De Bleecker 13, Jan; Van den Abeele 13, Guy; de Koning 13, Kathy; De Mey 13, Katrien; Mercelis 14, Rudy; Mahieu 14, Délphine; Wagemaekers 14, Linda; Van Damme 15, Philip; Depreitere 16, Annelies; Schotte 16, Caroline; Smetcoren 16, Charlotte; Stevens 16, Olivier; Van Daele 16, Sien; Vandenbussche 16, Nicolas; Vanhee 16, Annelies; Verjans 16, Sarah; Vynckier 16, Jan; D'Hondt 16, Ann; Tilkin 16, Petra; Alves de Siqueira Carvalho 17, Alzira; Dias Brockhausen 17, Igor; Feder 17, David; Ambrosio 17, Daniel; César 17, Pamela; Paula Melo 17, Ana; Martins Ribeiro 17, Renata; Rocha 17, Rosana; Bezerra Rosa 17, Bruno; Veiga 17, Thabata; Augusto da Silva 17, Luiz; Santos Engel 17, Murilo; Gonçalves Geraldo 17, Jordana; da Penha Ananias Morita 18, Maria; Nogueira Coelho 18, Erica; Paiva 18, Gabriel; Pozo 18, Marina; Prando 18, Natalia; Dada Martineli Torres 18, Debora; Fernanda Butinhao 18, Cristiani; Duran 18, Gustavo; Cristina Gomes da Silva 18, Tamires; Otavio Maia Gonçalves 18, Luiz; Eduardo Pazetto 18, Lucas; Augusto Suriane Fialho 18, Tomás; Renata Cubas Volpe 18, Luciana; Souza Duca 18, Luciana; Souza Bulle Oliveira 19, Acary; Carolina Amaral Andrade 19, Ana; Annes 19, Marcelo; Duarte Silva 19, Liene; Cavalcante Lino 19, Valeria; Pinto 19, Wladimir; Assis 19, Natália; Carrara 19, Fernanda; Miranda 19, Carolina; Souza 19, Iandra; Fernandes 19, Patricia; Siddiqi 20, Zaeem; Phan 20, Cecile; Narayan 20, Jeffrey; Blackmore 20, Derrick; Mallon 20, Ashley; Roderus 20, Rikki; Watt 20, Elizabeth; Junkerova 21, Jana; Kurkova 21, Barbora; Reguliova 21, Katarina; Zapletalova 21, Olga; Pitha 22, Jiri; Novakova 22, Iveta; Tyblova 22, Michaela; Jurajdova 22, Ivana; Wolfova 22, Marcela; Andersen 23, Henning; Harbo 23, Thomas; Vinge 23, Lotte; Krogh 23, Susanne; Mogensen 23, Anita; Vissing 24, John; Højgaard 24, Joan; Witting 24, Nanna; Mette Ostergaard Autzen 24, Anne; Pedersen 24, Jane; Eralinna 25, Juha-Pekka; Laaksonen 25, Mikko; Oksaranta 25, Olli; Harrison 25, Tuula; Eriksson 25, Jaana; Rozsa 26, Csilla; Horvath 26, Melinda; Lovas 26, Gabor; Matolcsi 26, Judit; Szabo 26, Gyorgyi; Jakab 26, Gedeonne; Szabadosne 26, Brigitta; Antonini 27, Giovanni; Di Pasquale 27, Antonella; Garibaldi 27, Matteo; Morino 27, Stefania; Troili 27, Fernanda; Fionda 27, Laura; Filla, Allessandro; Costabile, Teresa; Marano, Enrico; Saccà, Francesco; Fasanaro, Angiola; Marsili, Angela; Puorro, Giorgia; Mantegazza 29, Renato; Antozzi 29, Carlo; Bonanno 29, Silvia; Camera 29, Giorgia; Locatelli 29, Alberta; Maggi 29, Lorenzo; Pasanisi 29, Maria; Campanella 29, Angela; Evoli 30, Amelia; Emilio Alboini 30, Paolo; D'Amato 30, Valentina; Iorio 30, Raffaele; Kanai 31, Tetsuya; Kawaguchi 31, Naoki; Mori 31, Masahiro; Kaneko 31, Yoko; Kanzaki 31, Akiko; Kobayashi 31, Eri; Masaki 32, Katsuhisa; Matsuse 32, Dai; Matsushita 32, Takuya; Uehara 32, Taira; Shimpo 32, Misa; Jingu 32, Maki; Kikutake 32, Keiko; Nakamura 32, Yumiko; Sano 32, Yoshiko; Nagane 33, Yuriko; Kamegamori 33, Ikuko; Tsuda 33, Tomoko; Fujii 33, Yuko; Futono 33, Kazumi; Ozawa 33, Yukiko; Mizugami 33, Aya; Saito 33, Yuka; Morikawa 34, Miyuki; Samukawa 34, Makoto; Kamakura 34, Sachiko; Miyawaki 34, Eriko; Mitazaki 35, Teiichiro; Motomura 35, Masakatsu; Mukaino 35, Akihiro; Yoshimura 35, Shunsuke; Asada 35, Shizuka; Yoshida 35, Seiko; Amamoto 35, Shoko; Kobashikawa 35, Tomomi; Koga 35, Megumi; Maeda 35, Yasuko; Takada 35, Kazumi; Takada 35, Mihoko; Tsurumaru 35, Masako; Yamashita 35, Yumi; Akiyama 36, Tetsuya; Narikawa 36, Koichi; Tano 36, Ohito; Tsukita 36, Kenichi; Kurihara 36, Rikako; Meguro 36, Fumie; Fukuda 36, Yusuke; Sato 36, Miwako; Funaka 37, Soichiro; Kawamura 37, Tomohiro; Makamori 37, Masayuki; Takahashi 37, Masanori; Taichi 37, Namie; Hasuike 37, Tomoya; Higuchi 37, Eriko; Kobayashi 37, Hisako; Osakada 37, Kaori; Tsuda 38, Emiko; Shimohama 38, Shun; Hayashi 38, Takashi; Hisahara 38, Shin; Kawamata 38, Jun; Murahara 38, Takashi; Saitoh 38, Masaki; Suzuki 38, Shuichiro; Yamamoto 38, Daisuke; Ishiyama 38, Yoko; Ishiyama 38, Naoko; Noshiro 38, Mayuko; Takeyama 38, Rumi; Uwasa 38, Kaori; Yasuda 38, Ikuko; van der Kooi 39, Anneke; de Visser 39, Marianne; Gibson 39, Tamar; Casasnovas 40, Carlos; Antonia Alberti Aguilo 40, Maria; Homedes-Pedret 40, Christian; Julia Palacios 40, Natalia; Diez Porras 40, Laura; Velez Santamaria 40, Valentina; Lazaro 40, Ana; Diez Tejedor 41, Exuperio; Gomez Salcedo 41, Pilar; Fernandez-Fournier 41, Mireya; Lopez Ruiz 41, Pedro; Javier Rodriguez de Rivera 41, Francisco; Sastre 41, Maria; Gamez 42, Josep; Sune 42, Pilar; Salvado 42, Maria; Gili 42, Gisela; Mazuela 42, Gonzalo; Illa 43, Isabel; Cortes Vicente 43, Elena; Diaz-Manera 43, Jordi; Antonio Querol Gutierrez 43, Luis; Rojas Garcia 43, Ricardo; Vidal 43, Nuria; Arribas-Ibar 43, Elisabet; Piehl 44, Fredrik; Hietala 44, Albert; Bjarbo 44, Lena; Sengun 45, Ihsan; Meherremova 45, Arzu; Ozcelik 45, Pinar; Balkan 45, Bengu; Tuga 45, Celal; Ugur 45, Muzeyyen; Erdem-Ozdamar 46, Sevim; Ebru Bekircan-Kurt 46, Can; Pinar Acar 46, Nazire; Yilmaz 46, Ezgi; Caliskan 46, Yagmur; Orsel 46, Gulsah; Efendi 47, Husnu; Aydinlik 47, Seda; Cavus 47, Hakan; Kutlu 47, Ayse; Becerikli 47, Gulsah; Semiz 47, Cansu; Tun 47, Ozlem; Terzi 48, Murat; Dogan 48, Baki; Kazim Onar 48, Musa; Sen 48, Sedat; Kirbas Cavdar 48, Tugce; Veske 48, Adife; Norwood 49, Fiona; Dimitriou 49, Aikaterini; Gollogly 49, Jakit; Mahdi-Rogers 49, Mohamed; Seddigh 49, Arshira; Sokratous 49, Giannis; Maier 49, Gal; Sohail 49, Faisal; Jacob 50, Saiju; Sadalage 50, Girija; Torane 50, Pravin; Brown 50, Claire; Shah 50, Amna; Sathasivam 51, Sivakumar; Arndt 51, Heike; Davies 51, Debbie; Watling 51, Dave; Amato 52, Anthony; Cochrane 52, Thomas; Salajegheh 52, Mohammed; Roe 52, Kristen; Amato 52, Katherine; Toska 52, Shirli; Wolfe 53, Gil; Silvestri 53, Nicholas; Patrick 53, Kara; Zakalik 53, Karen; Katz 54, Jonathan; Miller 54, Robert; Engel 54, Marguerite; Forshew 54, Dallas; Bravver 55, Elena; Brooks 55, Benjamin; Plevka 55, Sarah; Burdette 55, Maryanne; Cunningham 55, Scott; Sanjak 55, Mohammad; Kramer 55, Megan; Nemeth 55, Joanne; Schommer 55, Clara; Tierney 55, Scott; Juel 56, Vern; Guptill 56, Jeffrey; Hobson-Webb 56, Lisa; Massey 56, Janice; Beck 56, Kate; Carnes 56, Donna; Loor 56, John; Anderson 56, Amanda; Pascuzzi 57, Robert; Bodkin 57, Cynthia; Kincaid 57, John; Snook 57, Riley; Guingrich 57, Sandra; Micheels 57, Angela; Chaudhry 58, Vinay; Corse 58, Andrea; Mosmiller 58, Betsy; Kelley 58, Andrea; Ho 59, Doreen; Srinivasan 59, Jayashri; Vytopil 59, Michal; Jara 59, Jordan; Ventura 59, Nicholas; Scala 59, Stephanie; Carter 59, Cynthia; Donahue 59, Craig; Herbert 59, Carol; Weiner 59, Elaine; Alam 59, Sharmeen; McKinnon 60, Jonathan; Haar 60, Laura; McKinnon 60, Naya; Alcon 60, Karan; McKenna 60, Kaitlyn; Sattar 60, Nadia; Daniels 60, Kevin; Jeffery 60, Dennis; Freimer 61, Miriam; Chad Hoyle 61, Joseph; Kissel 61, John; Agriesti 61, Julie; Chelnick 61, Sharon; Mezache 61, Louisa; Pineda 61, Colleen; Muharrem 61, Filiz; Karam 62, Chafic; Khoury 62, Julie; Marburger 62, Tessa; Kaur 62, Harpreet; Dimitrova 62, Diana; Gilchrist 63, James; Agrawal 63, Brajesh; Elsayed 63, Mona; Kohlrus 63, Stephanie; Andoin 63, Angela; Darnell 63, Taylor; Golden 63, Laura; Lokaitis 63, Barbara; Seelback 63, Jenna; Muppidi 64, Srikanth; Goyal 64, Neelam; Sakamuri 64, Sarada; T So 64, Yuen; Paulose 64, Shirley; Pol 64, Sabrina; Welsh 64, Lesly; Bhavaraju-Sanka 65, Ratna; Tobon Gonzales 65, Alejandro; Dishman 65, Lorraine; Jones 65, Floyd; Gonzalez 65, Anna; Padilla 65, Patricia; Saklad 65, Amy; Silva 65, Marcela; Kazamel 66, Mohamed; Alsharabati 66, Mohammad; Lu 66, Liang; Nozaki 66, Kenkichi; Mumfrey-Thomas 66, Sandi; Woodall 66, Amy; Mozaffar 67, Tahseen; Cash 67, Tiyonnoh; Goyal 67, Namita; Roy 67, Gulmohor; Mathew 67, Veena; Maqsood 67, Fatima; Minton 67, Brian; James Jones 68, H; Rosenfeld 68, Jeffrey; Garcia 68, Rebekah; Echevarria 68, Laura; Garcia 68, Sonia; Pulley 69, Michael; Aranke 69, Shachie; Ross Berger 69, Alan; Shah 69, Jaimin; Shabbir 69, Yasmeen; Smith 69, Lisa; Varghese 69, Mary; Gutmann 70, Laurie; Gutmann 70, Ludwig; Jerath 70, Nivedita; Nance 70, Christopher; Swenson 70, Andrea; Olalde 70, Heena; Kressin 70, Nicole; Sieren 70, Jeri; Barohn 71, Richard; Dimachkie 71, Mazen; Glenn 71, Melanie; McVey 71, April; Pasnoor 71, Mamatha; Statland 71, Jeffery; Wang 71, Yunxia; Liu 71, Tina; Emmons 71, Kelley; Jenci 71, Nicole; Locheke 71, Jerry; Fondaw 71, Alex; Johns 71, Kathryn; Rico 71, Gabrielle; Walsh 71, Maureen; Herbelin 71, Laura; Hafer-Macko 72, Charlene; Kwan 72, Justin; Zilliox 72, Lindsay; Callison 72, Karen; Young 72, Valerie; DiSanzo 72, Beth; Naunton 72, Kerry; Benatar 73, Michael; Bilsker 73, Martin; Sharma 73, Khema; Cooley 73, Anne; Reyes 73, Eliana; Michon 73, Sara-Claude; Sheldon 73, Danielle; Steele 73, Julie; Howard Jr 74, James; Karam 74, Chafic; Chopra 74, Manisha; Traub 74, Rebecca; Vu 75, Tuan; Katzin 75, Lara; McClain 75, Terry; Harvey 75, Brittany; Hart 75, Adam; Huynh 75, Kristin; Beydoun 76, Said; Chilingaryan 76, Amaiak; Doan 76, Victor; Droker 76, Brian; Gong 76, Hui; Karimi 76, Sanaz; Lin 76, Frank; McClain 76, Terry; Pokala 76, Krishna; Shah 76, Akshay; Tran 76, Anh; Akhter 76, Salma; Malekniazi 76, Ali; Tandan 77, Rup; Hehir 77, Michael; Waheed 77, Waqar; Lucy 77, Shannon; Weiss 78, Michael; Distad 78, Jane; Strom 78, Susan; Downing 78, Sharon; Kim 78, Bryan; Nowak 79, Richard; Dicapua 79, Daniel; Keung 79, Benison; Kumar 79, Aditya; Patwa 79, Huned; Robeson 79, Kimberly; Yang 79, Irene; Nye 79, Joan; ., Hong Vu. - In: JOURNAL OF THE NEUROLOGICAL SCIENCES. - ISSN 0022-510X. - 407:(2019), p. 116419. [10.1016/j.jns.2019.08.004]