IRIS
SEPE, VALENTINA
 Distribuzione geografica
Salva come PNG Salva come JPEG
Continente #
NA - Nord America 1.833
EU - Europa 1.257
AS - Asia 767
AF - Africa 46
SA - Sud America 4
Continente sconosciuto - Info sul continente non disponibili 1
OC - Oceania 1
Totale 3.909
Salva come PNG Salva come JPEG
Nazione #
US - Stati Uniti d'America 1.793
IT - Italia 745
SG - Singapore 400
CN - Cina 273
IE - Irlanda 119
FI - Finlandia 118
DE - Germania 60
UA - Ucraina 60
NL - Olanda 43
CA - Canada 35
GB - Regno Unito 30
IN - India 26
VN - Vietnam 24
CI - Costa d'Avorio 23
SE - Svezia 21
MA - Marocco 20
RU - Federazione Russa 20
FR - Francia 16
JP - Giappone 12
ID - Indonesia 10
KR - Corea 7
HK - Hong Kong 5
BE - Belgio 4
CH - Svizzera 4
ES - Italia 4
MX - Messico 4
TR - Turchia 4
PT - Portogallo 3
AR - Argentina 2
CL - Cile 2
KE - Kenya 2
PK - Pakistan 2
PL - Polonia 2
PS - Palestinian Territory 2
A1 - Anonimo 1
AE - Emirati Arabi Uniti 1
AT - Austria 1
AU - Australia 1
BY - Bielorussia 1
CZ - Repubblica Ceca 1
EG - Egitto 1
GR - Grecia 1
IM - Isola di Man 1
PA - Panama 1
RO - Romania 1
RS - Serbia 1
SK - Slovacchia (Repubblica Slovacca) 1
TW - Taiwan 1
Totale 3.909
Salva come PNG Salva come JPEG
Città #
Chandler 323
Singapore 318
Naples 175
Santa Clara 161
Napoli 116
Millbury 106
Princeton 95
Ashburn 84
Nanjing 78
Boston 75
Jacksonville 69
Beijing 51
Wilmington 41
Des Moines 40
Ottawa 33
Amsterdam 31
Salerno 26
Munich 25
Shenyang 25
Dong Ket 24
Helsinki 21
Torre Annunziata 21
Casablanca 20
Nanchang 19
Pune 19
Lawrence 18
Hebei 17
Houston 15
Rome 14
Tianjin 14
Boardman 13
Formia 13
Changsha 11
Falls Church 11
Seattle 10
Norwalk 9
Perugia 9
Angri 8
Jakarta 8
Jiaxing 8
Sesto Fiorentino 8
Redwood City 7
Shanghai 7
Ercolano 6
Kronberg 6
Tokyo 6
Cambridge 5
Frattamaggiore 5
Los Angeles 5
Monza 5
Rende 5
Fairfield 4
Indiana 4
Kunming 4
Lappeenranta 4
Milan 4
Moscow 4
New York 4
Redmond 4
Regensburg 4
San Leucio 4
Sparanise 4
Turin 4
Woodbridge 4
Afragola 3
Changchun 3
Hangzhou 3
Langhirano 3
Okayama 3
Palermo 3
Queenstown Estate 3
San Francisco 3
San Gennaro Vesuviano 3
San Giorgio A Cremano 3
San Mateo 3
Sarno 3
Shenzhen 3
Trieste 3
Varedo 3
Vietri Sul Mare 3
Washington 3
Yonkers 3
Ann Arbor 2
Bologna 2
Brugherio 2
Brussels 2
Burlington 2
Caivano 2
Caserta 2
Córdoba 2
Dallas 2
Dublin 2
Hong Kong 2
Irpin 2
London 2
Nairobi 2
Niscemi 2
Nutley 2
Orta di Atella 2
Pacos de Brandao 2
Totale 2.381
Salva come PNG Salva come JPEG
Nome #
2° International Summer School on Natural Products 75
Discovery of UDCA derivatives as new modulators of bile acid receptors 69
Design, synthesis and pharmacological characterization of novel potent nonsteroidal agonists of the farnesoid X receptor 69
Identification of cysteinyl-leukotriene-receptor 1 antagonists as ligands for the bile acid receptor GPBAR1 62
Targeting bile acid receptors: discovery of a potent and selective Farnesoid X receptor agonist as a new lead in the pharmacological approach to liver diseases 61
Novel Isoxazole Derivatives with Potent FXR Agonistic Activity Prevent Acetaminophen-Induced Liver Injury 61
Hijacking SARS-CoV-2/ACE2 Receptor Interaction by Natural and Semi-synthetic Steroidal Agents Acting on Functional Pockets on the Receptor Binding Domain 59
Discovery of a Potent and Orally Active Dual GPBAR1/CysLT1R Modulator for the Treatment of Metabolic Fatty Liver Disease 59
Bile acid modulators for the treatment of nonalcoholic steatohepatitis (NASH) 57
Synthesis, Pharmacological Evaluation, and Molecular Modeling Studies of Novel Peptidic CAAX Analogues as Farnesyl-Protein-Transferase Inhibitors 56
Identification of new GPBAR1 selective agonists containing an epoxide group on cholane side chains 56
Insights on FXR selective modulation. Speculation on bile acid chemical space in the discovery of potent and selective agonists 54
Triterpenoid profile and bioactivity study of Oenothera maritima 53
Design, synthesis, and biological evaluation of potent dual agonists of nuclear and membrane bile acid receptors 53
Bile acids derivatives in the selective modulation of FXR and GP-BAR1 53
Synthesis of new isoxazole derivatives as fxr agonists with improved pharmacokinetic properties 53
Concise synthesis of AHMHA unit in perthamide C. Structural and stereochemical revision of perthamide C 52
Modification on Ursodeoxycholic Acid (UDCA) Scaffold. Discovery of Bile Acid Derivatives As Selective Agonists of Cell-Surface G-Protein Coupled Bile Acid Receptor 1 (GP-BAR1) 51
Introduction of Nonacidic Side Chains on 6-Ethylcholane Scaffolds in the Identification of Potent Bile Acid Receptor Agonists with Improved Pharmacokinetic Properties 50
Discovery of a Novel Class of Dual GPBAR1 Agonists-RORγt Inverse Agonists for the Treatment of IL-17-Mediated Disorders 49
Marine and semi-sinthetic hydroxystroids as new scaffolds for pregnane X receptor modulation 49
Callipeltins F-I: new antifungal peptides from the marine sponge Latrunculia sp. 48
Synthesis of a new class of isoxazole derivatives with a dual FXR agonistic and COX-2 inhibitory activity. 47
Impaired Itching Perception in Murine Models of Cholestasis Is Supported by Dysregulation of GPBAR1 Signaling 46
Solomonamides A and B: two unprecedented cyclic peptides from the marine sponge Theonella swinhoei 45
Farnesoid X receptor modulators 2014-present: a patent review 45
Potent dual agonists of nuclear and membrane bile acid receptors 44
The first total synthesis of solomonsterol B, a marine pregnane X receptor agonist 44
Conicasterol E, a small heterodimer partner sparing farnesoid-X-receptor modulator endowed with a pregnane-X-receptor agonistic activity, from the marine sponge Theonella swinhoei 43
Exploitation of Cholane Scaffold for the Discovery of Potent and Selective Farnesoid X Receptor (FXR) and G-Protein Coupled Bile Acid Receptor 1 (GP-BAR1) Ligands 43
Bile acids derivatives in the selective modulation of FXR and GPBAR1 43
Investigation on bile acid receptor regulators. Discovery of cholanoic acid derivatives with dual G-protein coupled bile acid receptor 1 (GPBAR1) antagonistic and farnesoid X receptor (FXR) modulatory activity 42
Phallusiasterols A and B: two new sulfated sterols from the Mediterranean tunicate Phallusia fumigata and their effects as modulators of the PXR receptor 41
Structure-based drug design targeting the cell membrane receptor GPBAR1: exploiting the bile acid scaffold towards selective agonism 41
Navigation in bile acid chemical space: discovery of novel FXR and GPBAR1 ligands 41
Structural Basis for Developing Multitarget Compounds Acting on Cysteinyl Leukotriene Receptor 1 and G-Protein-Coupled Bile Acid Receptor 1 41
Discovery of Bile Acid Derivatives as Potent ACE2 Activators by Virtual Screening and Essential Dynamics 41
Critical surveys covering the year 2005: total synthesis of natural products 40
Isolation of Plakinamine I: a new steroidal alkaloid from the marine sponge Corticium sp. and synthesis of an analogue model compound 40
Rational Drug Design of New Selective Modulators of GPBAR1 40
The First Total Synthesis of Solomonsterol B, a Marine Pregnane X Receptor Agonist 39
Discovery of cholanoic acid derivatives as new modulators of bile acid receptors 39
Design, Synthesis, and Pharmacological Evaluation of Dual FXR-LIFR Modulators for the Treatment of Liver Fibrosis 38
Discovery of Sulfated Sterols from Marine Invertebrates as a New Class of Marine Natural Antagonists of Farnesoid-X-Receptor 38
Synthesis of new bile acids derivatives as selective FXR/GPBAR1 ligands 38
Epoxide functionalization on cholane side chains in the identification of G-protein coupled bile acid receptor (GPBAR1) selective agonists 38
Synthesis of a new class of isoxazole derivatives with a dual FXR agonistic and COX-2 inhibitory activity 38
Conicasterol E, a Small Heterodimer Partner Sparing Farnesoid X Receptor Modulator Endowed with a Pregnane X Receptor Agonistic Activity, from the Marine Sponge Theonella swinhoei 35
Marine natural products as modulators of nuclear receptors 35
Towards FXR selectivity: manipulation of 6-ethylcholane scaffold 35
Farnesoid X receptor modulators (2011 - 2014): a patent review 34
Stereochemical assignment of the C23-C35 portion of sphinxolode/reidispongiolide class of natural products by asymmetric synthesis 34
Towards new ligands of nuclear receptors. Discovery of malaitasterol A, an unique bis-secosterol from marine sponge Theonella swinhoei 34
Isolation and structural elucidation of callipeltins J-M: antifungal peptides from the marine sponge Latrunculia sp 33
Discovery of amine bile acid derivatives as selective agonists of cell-surface G-protein coupled bile acid receptor 1 33
Discovery of new dual GPBAR1 /RORγt modulators with promising activity in the treatment of inflammation diseases 32
Sintesi e caratterizzazione farmacologica di nuovi chemioterapici antitumorali inibitori della farnesil-transferasi 32
Modification in the side chain of solomonsterol A: discovery of cholestan disulfate as a potent pregnane-X-receptor agonist 32
Insight on pregnane-X-receptor modulation. Natural and semisynthetic steroids from Theonella marine sponges 30
Preliminary SAR on theonellasterol, a new chemotype of FXR antagonist, from the marine sponge Theonella swinhoei 30
Perthamides C and D, two new potent anti-inflammatory cyclopeptides from a Solomon Lithistid sponge Theonella swinhoei 29
Preliminary structure-activity relationship on theonellasterol, a new chemotype of FXR antagonist, from the marine sponge Theonella swinhoei 29
Navigation in bile acid chemical space: discovery of novel FXR and GPBAR1 modulators 29
Speculation on 6-ethylcholane scaffold in the discovery of novel FXR and GPBAR1 ligands. 29
Concise Synthesis of All Stereoisomers of b-Methoxytyrosine and Determination of the Absolute Configuration of the Residue in Callipeltin A 28
Bioactive peptides from sponges of the Lithistida order 28
Repositioning Mifepristone as a Leukaemia Inhibitory Factor Receptor Antagonist for the Treatment of Pancreatic Adenocarcinoma 27
Thiazolidin-4-one-based compounds interfere with the eicosanoid biosynthesis pathways by mPGES-1/sEH/5-LO multi-target inhibition 27
null 27
Jaspamides M-P: new tryptophan modified jaspamide derivatives from the sponge Jaspis splendans 27
Total Synthesis and Pharmacological Characterization of Solomonsterol A, a Potent Marine Pregnane-X-Receptor Agonist Endowed with Anti-Inflammatory Activity. 27
FXR mediates a chromatin looping in the GR promoter thus promoting the resolution of colitis in rodents 27
Marine compounds as modulators of metabolic nuclear receptors: isolation, design, total synthesis and potential therapeutic application 27
Towards FXR selectivity: manipulation of 6-ethylcholane scaffold 27
Modification on bile acid scaffold in the identification of FXR and GP-BAR1 modulation 26
Combinatorial targeting of G-protein-coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug-induced liver injury 25
Theonellasterone, a steroidal metabolite isolated from a Theonella sponge, protects peroxiredoxin-1 from oxidative stress reactions 25
Progressi verso la definizione della stereochimica e la sintesi totale degli sfinxolidi 24
Modification of semisynthetic bile acid derivatives as human receptor modulators 24
Solomonamides A and B, new anti-inflammatory peptides from Theonella swinhoei 23
Theonellasterol: a highly selective FXR antagonist that protects against liver injury in cholestasis 23
Perthamides C-F, potent human antipsoriatic cyclopeptides 23
Natural and semisynthetic bile acids as Leukemia Inhibitory Factor (LIF) receptor antagonists 22
Isolation of new derivates of callipeltin C from the marine sponge Latrunculia sp. 22
Perthamides C and D, two new cyclopeptides from the marine sponge Theonella swinhoei 22
Progettazione, Sintesi e analisi conformazionale di una nuova libreria di analoghi strutturali dell’agente antitumorale Jaspamide 21
Structural studies on Homophymine A, a new cyclodepsipeptide with anti-HIV activity from a new Caledonian Lithistide sponge 21
Incisterols, highly degraded marine sterols, are a new chemotype of PXR agonists 21
I International Summer School on Natural Products (ISSNP 2015) 21
Discovery of BAR502, as potent steroidal antagonist of leukemia inhibitory factor receptor for the treatment of pancreatic adenocarcinoma 20
Synthetic and pharmacological studies on new simplified analogues of the potent actin-targeting Jaspamide 20
Synthetic studies on homophymine A: stereoselective synthesis of (2R,3R,4R,6R)-3-hydroxy-2,4,6-trimethyloctanoic acid 20
Synthetic studies on Perthamide C 20
A new steroid from the marine sponge Corticium sp. and a expedient synthesis of its analogue model compound 20
Perthamides C-F, potent human antipsoriatic cyclopeptides 20
From Nature to the Bench 20
Homophymine A, an Anti-HIV Cyclodepsipeptide from the Sponge Homophymia sp 19
Towards new ligands of nuclear receptors. Discovery of malaitasterol A, an unique bis-secosterol from marine sponge Theonella swinhoei 19
Solomonsterol A, a marine pregnane-X-receptor agonist, attenuates inflammation and immune dysfunction in a mouse model of arthritis 19
Marine and semi-synthetic hydroxysteroids as new scaffolds for pregnane x receptor modulation. 19
Totale 3.660
Salva come PNG Salva come JPEG
Categoria #
all - tutte 18.708
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 18.708
Salva come PNG Salva come JPEG


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/2020171 0 0 0 0 0 10 15 36 4 28 46 32
2020/2021355 7 26 39 20 44 72 25 15 38 15 15 39
2021/2022624 19 12 7 1 4 24 25 44 128 24 68 268
2022/2023751 124 57 11 69 100 88 11 74 131 29 41 16
2023/2024644 49 84 76 17 28 56 27 57 23 31 144 52
2024/2025856 172 251 31 78 76 248 0 0 0 0 0 0
Totale 4.158