IRIS
PIGNATARO, GIUSEPPE
 Distribuzione geografica
Salva come PNG Salva come JPEG
Continente #
NA - Nord America 2.682
EU - Europa 1.713
AS - Asia 846
AF - Africa 49
SA - Sud America 4
Continente sconosciuto - Info sul continente non disponibili 1
OC - Oceania 1
Totale 5.296
Salva come PNG Salva come JPEG
Nazione #
US - Stati Uniti d'America 2.617
IT - Italia 893
SG - Singapore 438
CN - Cina 326
NL - Olanda 179
DE - Germania 176
FI - Finlandia 117
UA - Ucraina 103
IE - Irlanda 92
CA - Canada 63
CI - Costa d'Avorio 48
GB - Regno Unito 47
SE - Svezia 44
FR - Francia 26
VN - Vietnam 26
TR - Turchia 18
RU - Federazione Russa 17
IN - India 16
JP - Giappone 6
HK - Hong Kong 5
AT - Austria 3
CL - Cile 3
ES - Italia 3
TW - Taiwan 3
BE - Belgio 2
HU - Ungheria 2
IR - Iran 2
MX - Messico 2
PL - Polonia 2
SA - Arabia Saudita 2
AR - Argentina 1
AU - Australia 1
BG - Bulgaria 1
CH - Svizzera 1
EG - Egitto 1
EU - Europa 1
GE - Georgia 1
GR - Grecia 1
ID - Indonesia 1
KG - Kirghizistan 1
KR - Corea 1
NO - Norvegia 1
PT - Portogallo 1
RO - Romania 1
RS - Serbia 1
Totale 5.296
Salva come PNG Salva come JPEG
Città #
Chandler 485
Ashburn 372
Singapore 365
Amsterdam 171
Napoli 167
Naples 166
Santa Clara 138
Millbury 127
Jacksonville 117
Princeton 93
Beijing 70
Nanjing 70
Boston 67
Ottawa 59
Wilmington 42
Des Moines 37
Lawrence 30
Woodbridge 29
Nanchang 27
Barano d'Ischia 26
Helsinki 25
Dong Ket 24
Dearborn 23
Formia 20
Seattle 20
Rome 19
Milan 18
Norwalk 16
Jiaxing 15
Los Angeles 15
Shenyang 15
Caserta 13
Hebei 12
Houston 12
Pune 12
Changsha 11
Kronberg 11
Florence 10
Afragola 9
Boardman 9
Sudbury 9
Tianjin 9
Dublin 8
Hangzhou 8
Portici 8
Rende 8
Salerno 8
Washington 8
Ercolano 7
Fairfield 7
Falkenstein 7
Frankfurt am Main 7
Mugnano di Napoli 7
Zhengzhou 7
Falls Church 6
Kunming 6
Moscow 6
Nocera Inferiore 6
Palermo 6
Redwood City 6
Vasanello 6
Baronissi 5
Dallas 5
Indiana 5
Jinan 5
Lappeenranta 5
Orange 5
Pozzuoli 5
Acri 4
Ann Arbor 4
Canegrate 4
Castellammare di Stabia 4
Hong Kong 4
Ningbo 4
Pavullo Nel Frignano 4
Redmond 4
Sant'arpino 4
Shanghai 4
Yalta 4
Abano Terme 3
Bari 3
Fort Worth 3
Guangzhou 3
Mansfield 3
Modena 3
Mountain View 3
New York 3
Nürnberg 3
Perugia 3
Saint Paul 3
San Giorgio Del Sannio 3
Scuola 3
Taipei 3
Ariano Irpino 2
Augusta 2
Avellino 2
Brusciano 2
Brussels 2
Budapest 2
Canterbury 2
Totale 3.252
Salva come PNG Salva come JPEG
Nome #
7-nitro-5-fenil-1(pirrolidin-1-ilmetil)-1H-benzo[e][1,4] diazepin-2(3H)-one ed altri composti derivati delle benzodiazepine 320
Urokinase-type plasminogen activator receptor (uPAR) expression enhances invasion and metastasis in RAS mutated tumors 95
Divergent modulation of iron regulatory proteins and ferritin biosynthesis during hypoxia/reoxygenation affect neuronal death and glial cells survival 77
ncx1, ncx2, and ncx3 gene product expression and function in neuronal anoxia and brain ischemia. 73
Sp3/REST/HDAC1/HDAC2 complex represses and Sp1/HIF-1/p300 complex activates ncx1 gene transcription, in brain ischemia and in ischemic brain preconditioning, by Epigenetic mechanism 70
L’aumento dell’RNAm e della proteina HIF-1α, una subunità della proteina Hypoxia Inducible Factor (HIF-1), indotta dall’ischemia cerebrale, attiva il gene codificante per la iNOS 68
Acute and long-term NCX activation reduces brain injury and restores behavioral functions in mice subjected to neonatal brain ischemia 68
Hypoxia/reoxygenation differently modulates the activity of iron regulatory proteins and ferritin biosynthesis in rat glial cells and neurons 67
A critical role for the potassium-dependent sodium-calcium exchanger NCKX2 in protection against focal ischemic brain damage. 66
Neuronal NCX1 overexpression induces stroke resistance while knockout induces vulnerability via Akt 63
L’aumento dell’mRNA e della proteina HIF-1a, una subunità della proteina HIF-1 (Hypoxia Inducible Factor), indotta dall’ischemia cerebrale, attiva il gene codificante per la iNOS 62
The functional coupling between endoplasmic reticulum and lysosomes for intracellular Ca2+ handling is disrupted in brain ischemia 62
7-nitro-5-phenyl-1-(pyrrolidin-1-ylmethyl)-1H-benzo[E][1,4]diazepin-2(3H)-one and other benzodiazepine derivatives 61
NCX1 Exchanger Cooperates with Calretinin to Confer Preconditioning-Induced Tolerance Against Cerebral Ischemia in the Striatum. 59
Neuronal death and astrocytes survival during hypoxia/reoxygenation are affected by opposite modulation of Iron Regulatory Proteins and ferritin biosynthesis 59
Divergent modulation of iron regulatory proteins and ferritin biosynthesis by hypoxia/reoxygenation in neurones and glial cells 59
Alcohol increases spontaneous BOLD signal fluctuations in the visual network 58
Farmacologia per le professioni sanitarie 58
Anti-miR-223-5p Ameliorates Ischemic Damage and Improves Neurological Function by Preventing NCKX2 Downregulation after Ischemia in Rats 58
Pharmacological characterization of the newly synthesized 5-amino-N-butyl-2-(4-ethoxyphenoxy)-benzamide hydrochloride (BED) as a potent NCX3 inhibitor that worsens anoxic injury in cortical neurons, organotypic hippocampal cultures, and ischemic brain 56
Genetic ablation of homeodomain-interacting protein kinase 2 selectively induces apoptosis of cerebellar Purkinje cells during adulthood and generates an ataxic-like phenotype 54
Evidence for a protective role played by Na+-Ca2+ exchanger in cerebral ischemia induced by middle cerebral artery occlusion in male rats 52
Genetically modified mice as a strategy to unravel the role played by the na(+)/ca (2+) exchanger in brain ischemia and in spatial learning and memory deficits 52
Sodium/calcium exchanger as main effector of endogenous neuroprotection elicited by ischemic tolerance 52
Apoptosis induced in neuronal cells by oxidative stress: role played by caspases and intracellular calcium ions. 51
Stroke by inducing HDAC9-dependent deacetylation of HIF-1 and Sp1, promotes TfR1 transcription and GPX4 reduction, thus determining ferroptotic neuronal death 50
Apoptosis induced in neuronal cells by oxidative stress: role played by caspases and intracellular calcium ions 50
Does Na(+)/Ca (2+) Exchanger, NCX, Represent a New Druggable Target in Stroke Intervention? 50
Preconditioning, induced by sub-toxic dose of the neurotoxin L-BMAA, delays ALS progression in mice and prevents Na+/Ca2+exchanger 3 downregulation 50
Divergent modulation of Iron Regulatory Proteins and ferritin biosynthesis by hypoxia/reoxygenation in neurons and in glial cells 49
Neuroprotective Effect of VEGF-Mimetic Peptide QK in Experimental Brain Ischemia Induced in Rat by Middle Cerebral Artery Occlusion 49
Surgical Methods to Induce Brain Preconditioning 48
Farmaci Antimicotici 47
ASIC1a contributes to neuroprotection elicited by ischemic preconditioning and postconditioning 47
Neuroprotective coordination of cell mitophagy by the F1Fo-ATPase Inhibitory Factor 1 (IF1) 47
Apoptosis induced in neuronal cells by oxidative stress: role played by caspases and intracellular calcium ions. 46
Ionic Homeostasis Maintenance in ALS: Focus on New Therapeutic Targets 46
Apoptosis induced in neuronal cells by oxidative stress: role played by caspases and intracellular calcium ions. 45
HIF-1 alpha reveals a binding- activity to the promoter of iNOS gene after permanent middle cerebral artery occlusion 45
NCX1 Is a Novel Target Gene for Hypoxia-Inducible Factor-1 in Ischemic Brain Preconditioning 45
NCX1 is a new rest target gene: role in cerebral ischemia 45
Sumoylation of sodium/calcium exchanger in brain ischemia and ischemic preconditioning 45
Development validation of LC-MS/MS method and determination of pharmacokinetic parameters of the stroke neuroprotectant neurounina-1 in beagle dog plasma after intravenous administration 44
miR-206 Reduces the Severity of Motor Neuron Degeneration in the Facial Nuclei of the Brainstem in a Mouse Model of SMA 44
Targeted disruption of Na+/Ca2+ exchanger 3 (NCX3) gene leads to a worsening of ischemic brain damage. 43
Antithrombin reduces ischemic volume, ameliorates neurologic deficits, and prolongs animal survival in both transient and permanent focal ischemia 43
Multicentre translational Trial of Remote Ischaemic Conditioning in Acute Ischaemic Stroke (TRICS): protocol of multicentre, parallel group, randomised, preclinical trial in female and male rat and mouse from the Italian Stroke Organization (ISO) Basic Science network 43
In vivo imaging of CNS microglial activation/macrophage infiltration with combined [18F]DPA-714-PET and SPIO-MRI in a mouse model of relapsing remitting experimental autoimmune encephalomyelitis 42
Apoptosis induced in neuronal cells by oxidative stress: role played by caspases and intracellular calcium ions. 41
Transcriptional Regulation of ncx1 Gene in the Brain 41
Glutamate-independent calcium toxicity: Introduction. 40
Sumoylation of LYS590 of NCX3 f-Loop by SUMO1 Participates in Brain Neuroprotection Induced By Ischemic Preconditioning 40
HDAC4 and HDAC5 form a complex with DREAM that epigenetically down-regulates NCX3 gene and its pharmacological inhibition reduces neuronal stroke damage 40
Prolonged NCX activation prevents SOD1 accumulation, reduces neuroinflammation, ameliorates motor behavior and prolongs survival in a ALS mouse model 40
Uso dell'Antitrombina III (ATIII) per la preparazione di formulazioni farmaceutiche per uso parenterale per il trattamento dei danni cerebrali secondari all'insulto ischemico o ad altre malattie degenerative del sistema nervoso centrale e periferico 39
Effects of bone marrow mesenchymal stem cells (BM-MSCs) on rat pial microvascular remodeling after transient middle cerebral artery occlusion 39
Glial Na(+) -dependent ion transporters in pathophysiological conditions 39
ORAI1/STIM1 INTERACTION INTERVENES IN STROKE AND IN NEUROPROTECTION INDUCED BY ISCHEMIC PRECONDITIONING THROUGH ER Ca2+ REFILLING 39
Neurobiology of coronaviruses: Potential relevance for COVID-19 39
Use of CMOS Image Sensor for early detection of ischemic and haemorrhagic stroke 39
Beyond Retigabine: Design, Synthesis, and Pharmacological Characterization of a Potent and Chemically Stable Neuronal Kv7 Channel Activator with Anticonvulsant Activity 38
Apoptosis induced in neuronal cells by oxidative stress: role played by caspases and intracellular calcium ions 38
The NCX3 isoform of the Na(+)/Ca(2+) exchanger contributes to neuroprotection elicited by ischemic postconditioning 38
1st Joint Meeting Italian Israel Society for Neuroscience 38
Remote postconditioning ameliorates stroke damage by preventing let-7a and miR-143 up-regulation 38
Models and methods for conditioning the ischemic brain 37
Preconditioning and Postconditioning Exert Stroke Neuroprotection Modulating NCX and ASIC1a Expression 36
Ionic homeostasis in brain conditioning 36
Na+/Ca2+ exchanger in Na+ efflux-Ca2+ influx mode of operation exerts a neuroprotective role in cellular models of in vitro anoxia and in vivo cerebral ischemia. 35
Glutamate-independent calcium toxicity: introduction 35
Clinical Trials with Drugs Targeting Ionic Channels, Antiporters, and Pumps in Ischemic Stroke 35
Neurounina-1, a Novel Compound that Increases Na+/Ca2+ Exchanger Activity, Effectively Protects Against Stroke Damage 35
MicroRNA-103-1 Selectively Downregulates Brain NCX1 and Its Inhibition by Anti-miRNA Ameliorates Stroke Damage and Neurological Deficits 35
The hypoxia sensitive metal transcription factor MTF-1 activates NCX1 brain promoter and participates in remote postconditioning neuroprotection in stroke 35
Imaging of brain TSPO expression in a mouse model of amyotrophic lateral sclerosis with (18)F-DPA-714 and micro-PET/CT 35
NCX1 and NCX3: Two new effectors of delayed preconditioning in brain ischemia 34
GATA3 (GATA-binding protein 3)/KMT2A (lysine-methyltransferase-2A) complex by increasing H3K4-3me (trimethylated lysine-4 of histone-3) upregulates NCX3 (Na+-Ca2+exchanger 3) transcription and contributes to ischemic preconditioning neuroprotection 34
Na+/Ca2+ exchanger in Na+ efflux-Ca2+ influx mode of operation exerts a neuroprotective role in cellular models of in vitro anoxia and in vivo cerebral ischemia. 33
Acid-Sensing Ion Channels (ASICs): New Targets in Stroke Treatment 33
Synergistic association of valproate and resveratrol reduces brain injury in ischemic stroke 33
miR-16-5p, miR-103-3p, and miR-27b-3p as Early Peripheral Biomarkers of Fetal Growth Restriction 33
NEUROLOGICAL RISKS AND BENEFITS OF CYTOKINE-BASED TREATMENTS IN COVID-19: FROM PRECLINICAL TO CLINICAL EVIDENCE 33
New Insights into the Structure-Activity Relationship and Neuroprotective Profile of Benzodiazepinone Derivatives of Neurounina-1 as Modulators of the Na+/Ca2+Exchanger Isoforms 33
miR135a administration ameliorates brain ischemic damage by preventing TRPM7 activation during brain ischemia 32
Hypoxia/reoxygenation differently modulates Iron Regulatory Proteins activity and ferritin biosynthesis in glial cells and neurons 32
Two sodium/calcium exchanger gene products, NCX1 and NCX3, play a major role in the development of permanent focal cerebral ischemia. 32
The Na+/Ca2+ Exchanger: A Target for Therapeutic Intervention in Cerebral Ischemia 32
ORAI1/STIM1 Interaction Intervenes in Stroke and in Neuroprotection Induced by Ischemic Preconditioning Through Store-Operated Calcium Entry 32
Ruta graveolens water extract (RGWE) ameliorates ischemic damage and improves neurological deficits in a rat model of transient focal brain ischemia 32
Emerging Role of DREAM in Healthy Brain and Neurological Diseases 31
Neuroprotective, immunosuppressant and antineoplastic properties of mTOR inhibitors: current and emerging therapeutic options. 31
Conjunctival instillation of plasminogen eliminates ocular lesion in B6.129P2-Plg(tm1Jld) transgenic mice, a model of ligneous conjunctivitis 31
Hemorrhagic Stroke Induces a Time-Dependent Upregulation of miR-150-5p and miR-181b-5p in the Bloodstream 31
Uso dell'Antitrombina III (ATIII) per la preparazione di formulazioni farmaceutiche per uso parenterale per il trattamento dei danni cerebrali secondari all'insulto ischemico o ad altre malattie del sistema nervoso centrale e periferico 30
Acid-sensing ion channels (ASICs) as pharmacological targets for neurodegenerative diseases 30
Targeted acetylation of NF-kappaB/RelA and histones by epigenetic drugs reduces post-ischemic brain injury in mice with an extended therapeutic window 30
Ischemic tolerance modulates TRAIL expression and its receptors and generates a neuroprotected phenotype 30
Synthesis and Characterization of Novel Mono- and Bis-Guanyl Hydrazones as Potent and Selective ASIC1 Inhibitors Able to Reduce Brain Ischemic Insult 30
The 2-oxopyrrolidinacetamide piracetam reduces infarct brain volume induced by permanent middle cerebral artery occlusion in male rats. 29
Neuroprotective Role of Sodium/Calcium Exchanger, NCX1 and NCX3, in Ischemic Preconditioning 29
Totale 4.693
Salva come PNG Salva come JPEG
Categoria #
all - tutte 24.719
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 24.719
Salva come PNG Salva come JPEG


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/2020231 0 0 0 0 0 0 32 15 14 43 61 66
2020/2021409 21 34 37 27 45 56 39 13 47 10 40 40
2021/2022882 31 5 12 30 13 32 9 34 96 65 271 284
2022/20231.120 137 119 34 94 131 126 12 72 139 180 58 18
2023/20241.077 29 115 133 82 43 76 17 351 15 28 125 63
2024/2025843 176 216 24 58 104 259 6 0 0 0 0 0
Totale 5.505