Galanthamine is an alkaloid approved for the treatment of Alzheimer’s disease. In this paper the syntheses and the anticholinesterase activities of new glucosyl and nitroxy derivatives substituted on position 6 are reported. Compounds 2, 3 and 5 presented a percentage of inhibition of 35.22%, 47.48% and 67.89 % respectively
Synthesis of 6-beta-D-glucosyl and 6-nitroxy (-)-galanthamine derivatives as acetylcholinesterase inhibitors / Perissutti, Elisa; Fiorino, Ferdinando; Severino, Beatrice; Frecentese, Francesco; Massarelli, P; Nencini, C; Santagada, Vincenzo; Caliendo, Giuseppe. - In: PHARMAZIE. - ISSN 0031-7144. - ELETTRONICO. - 62:6(2007), pp. 403-405. [10.1691/ph.2007.6.6661]
Synthesis of 6-beta-D-glucosyl and 6-nitroxy (-)-galanthamine derivatives as acetylcholinesterase inhibitors
PERISSUTTI, ELISA;FIORINO, FERDINANDO;SEVERINO, BEATRICE;FRECENTESE, FRANCESCO;SANTAGADA, VINCENZO;CALIENDO, GIUSEPPE
2007
Abstract
Galanthamine is an alkaloid approved for the treatment of Alzheimer’s disease. In this paper the syntheses and the anticholinesterase activities of new glucosyl and nitroxy derivatives substituted on position 6 are reported. Compounds 2, 3 and 5 presented a percentage of inhibition of 35.22%, 47.48% and 67.89 % respectivelyI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
