In this paper, we describe the synthesis of conformationally constrained dipeptide mimetic derivatives. Microwave flash heating was used in several synthetic steps providing the opportunity to perform the reactions in dramatically shortened time as well as to increase the obtained yields. The efficiency of the methodology makes it useful in order to prepare other dipeptides containing the 4-amino-tetrahydro-2- benzazepin-3-one motif.
Efficient microwave-assisted synthesis of 4-amino-2-benzazepin-3-ones as conformationally restricted dipeptide mimetics / Severino, Beatrice; Fiorino, Ferdinando; A., Esposito; Frecentese, Francesco; F., De Angelis; Perissutti, Elisa; Caliendo, Giuseppe; Santagada, Vincenzo. - In: TETRAHEDRON. - ISSN 0040-4020. - ELETTRONICO. - 65:(2009), pp. 206-211. [10.1016/j.tet.2008.10.072]
Efficient microwave-assisted synthesis of 4-amino-2-benzazepin-3-ones as conformationally restricted dipeptide mimetics
SEVERINO, BEATRICE;FIORINO, FERDINANDO;FRECENTESE, FRANCESCO;PERISSUTTI, ELISA;CALIENDO, GIUSEPPE;SANTAGADA, VINCENZO
2009
Abstract
In this paper, we describe the synthesis of conformationally constrained dipeptide mimetic derivatives. Microwave flash heating was used in several synthetic steps providing the opportunity to perform the reactions in dramatically shortened time as well as to increase the obtained yields. The efficiency of the methodology makes it useful in order to prepare other dipeptides containing the 4-amino-tetrahydro-2- benzazepin-3-one motif.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
