Using DNA transfection analysis on NIH 3T3 cells, activated human oncogenes have been isolated from a variety of fresh solid tumours. Thyroid neoplasias show a wide range of lesions varying from slowly progressive well-differentiated tumours to anaplastic highly malignant neoplasms. Therefore they represent an attractive model to investigate the role of oncogene activation in different stages of the neoplastic state. Here we report the detection of transforming activity in DNAs extracted from five thyroid papillary carcinomas and two of their respective lymph-nodal metastases.
A new oncogene in human thyroid papillary carcinomas and their lymph-nodal metastases / Fusco, Alfredo; M., Grieco; Santoro, Massimo; M. T., Berlingieri; S., Pilotti; M. A., Pierotti; G., Della Porta; Vecchio, Giancarlo. - In: NATURE. - ISSN 0028-0836. - STAMPA. - 328:6126(1987), pp. 170-172.
A new oncogene in human thyroid papillary carcinomas and their lymph-nodal metastases
FUSCO, ALFREDO;SANTORO, MASSIMO;VECCHIO, GIANCARLO
1987
Abstract
Using DNA transfection analysis on NIH 3T3 cells, activated human oncogenes have been isolated from a variety of fresh solid tumours. Thyroid neoplasias show a wide range of lesions varying from slowly progressive well-differentiated tumours to anaplastic highly malignant neoplasms. Therefore they represent an attractive model to investigate the role of oncogene activation in different stages of the neoplastic state. Here we report the detection of transforming activity in DNAs extracted from five thyroid papillary carcinomas and two of their respective lymph-nodal metastases.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
