This paper outlines the synthesis and the pharmacological screening of a series of novel 1- and 2-[2-[4-(X)-1-piperazinyl]ethyl]benzotriazoles and 1-[3-[4-(X)-1-piperazinyl]propoxy]benzotriazoles, which are structurally related to trazodone. Anti serotonergic, antiadrenergic and antihistaminic in vitro activity and in vivo analgesic action are described. Some of the investigated compounds show overall pharmacological profiles similar to that of the antidepressant trazodone.
Synthesis and Biological Activity of Benzotriazole Derivatives Structurally Related to Trazodone / Caliendo, Giuseppe; DI CARLO, Raffaele; Greco, Giovanni; Meli, Rosaria; Novellino, Ettore; Perissutti, Elisa; Santagada, Vincenzo. - In: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. - ISSN 0223-5234. - STAMPA. - 30:1(1995), pp. 77-84. [10.1016/0223-5234(96)88212-2]
Synthesis and Biological Activity of Benzotriazole Derivatives Structurally Related to Trazodone.
CALIENDO, GIUSEPPE;DI CARLO, RAFFAELE;GRECO, GIOVANNI;MELI, ROSARIA;NOVELLINO, ETTORE;PERISSUTTI, ELISA;SANTAGADA, VINCENZO
1995
Abstract
This paper outlines the synthesis and the pharmacological screening of a series of novel 1- and 2-[2-[4-(X)-1-piperazinyl]ethyl]benzotriazoles and 1-[3-[4-(X)-1-piperazinyl]propoxy]benzotriazoles, which are structurally related to trazodone. Anti serotonergic, antiadrenergic and antihistaminic in vitro activity and in vivo analgesic action are described. Some of the investigated compounds show overall pharmacological profiles similar to that of the antidepressant trazodone.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
