Transcription factors (TFs) act downstream of the major signalling pathways functioning as master regulators of cell fate. Their activity is tightly regulated at the transcriptional, post-transcriptional and post-translational level. Proteins modifying TF activity are not easily identified by experimental high-throughput methods.
A reverse-engineering approach to dissect post-translational modulators of transcription factor's activity from transcriptional data / Gambardella, Gennaro; Peluso, Ivana; Montefusco, Sandro; Bansal, Mukesh; Medina, Diego L; Lawrence, Neil; DI BERNARDO, Diego; MEDINA SANABRIA, Diego Luis. - In: BMC BIOINFORMATICS. - ISSN 1471-2105. - 16:1(2015), p. 279. [10.1186/s12859-015-0700-3]
A reverse-engineering approach to dissect post-translational modulators of transcription factor's activity from transcriptional data
GAMBARDELLA, GENNARO;PELUSO, IVANA;BANSAL, MUKESH;DI BERNARDO, DIEGO;MEDINA SANABRIA, Diego Luis
2015
Abstract
Transcription factors (TFs) act downstream of the major signalling pathways functioning as master regulators of cell fate. Their activity is tightly regulated at the transcriptional, post-transcriptional and post-translational level. Proteins modifying TF activity are not easily identified by experimental high-throughput methods.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
