Inflammation in metabolically healthy and metabolically abnormal adolescents: The HELENA study

González-Gil, E. M.; Cadenas-Sanchez, C.; Santabárbara, J.; Bueno-Lozano, G.; Iglesia, I.; González-Gross, M.; Molnar, D.; Gottrand, F.; De Henauw, S.; Kafatos, A.; Widhalm, K.; Manios, Y.; Siani, A.; Amaro-Gahete, F.; Rupérez, A. I.; Cañada, D.; Censi, L.; Kersting, M.; Dallongeville, J.; Marcos, A.; Ortega, F. B.; Moreno, L. A.; Moreno, L. A.; Gottrand, F.; De Henauw, S.; González-Gross, M.; Gilbert, C.; Kafatos, A.; Libersa, C.; Castelló, S.; Kersting, M.; Sjöstrom, M.; Molnár, D.; Dallongeville, J.; Hall, G.; Maes, L.; Scalfi, L.; Meléndez, P.; Fleta, J.; Casajús, J. A.; Rodríguez, G.; Tomás, C.; Mesana, M. I.; Vicente-Rodríguez, G.; Villarroya, A.; Gil, C. M.; Ara, I.; Alvira, J. F.; Bueno, G.; Lázaro, A.; Bueno, O.; León, J. F.; Garagorri, J. Ma; Bueno, M.; Labayen, I.; Iglesia, I.; Bel Serrat, S.; Gracia Marco, L. A.; Mouratidou, T.; Santaliestra-Pasías, A.; González-Gil, E. M.; De Miguel-Etayo, P.; Julián Almárcegui, C.; Miguel-Berges, M.; Iguacel, I.; Marcos, A.; Wärnberg, J.; Nova, E.; Gómez, S.; Díaz, L. E.; Romeo, J.; Veses, A.; Zapatera, B.; Pozo, T.; Martínez, D.; Beghin, L.; Gottrand, F.; Iliescu, C.; Von Berlepsch, J.; Sichert-Hellert, W.; Koeppen, E.; Molnar, D.; Erhardt, E.; Csernus, K.; Török, K.; Bokor, S.; Angster, Null; Nagy, E.; Kovács, O.; Répasi, J.; Codrington, C.; Plada, M.; Papadaki, A.; Sarri, K.; Viskadourou, A.; Hatzis, C.; Kiriakakis, M.; Tsibinos, G.; Vardavas, C.; Sbokos, M.; Protoyeraki, E.; Fasoulaki, M.; Stehle, P.; Pietrzik, K.; Breidenassel, C.; Spinneker, A.; Al-Tahan, J.; Segoviano, M.; Berchtold, A.; Bierschbach, C.; Blatzheim, E.; Schuch, A.; Pickert, P.; Castillo, M. J.; Gutiérrez, Ã.; Ortega, F. B.; Ruiz, J. R.; Artero, E. G.; España, V.; Jiménez-Pavón, D.; Chillón, P.; Sánchez-Muñoz, C.; Cuenca, M.; Arcella, D.; Azzini, E.; Barrison, E.; Bevilacqua, N.; Buonocore, P.; Catasta, G.; Censi, L.; Ciarapica, D.; D'Acapito, P.; Ferrari, M.; Galfo, M.; Le Donne, C.; Leclercq, C.; Maiani, G.; Mauro, B.; Mistura, L.; Pasquali, A.; Piccinelli, R.; Polito, A.; Roccaldo, R.; Spada, R.; Sette, S.; Zaccaria, M.; Vitaglione, P.; Montagnese, C.; De Bourdeaudhuij, I.; De Vriendt, T.; Matthys, C.; Vereecken, C.; De Maeyer, M.; Ottevaere, C.; Huybrechts, I.; Widhalm, K.; Phillipp, K.; Dietrich, S.; Widhalm, K.; Phillipp, K.; Dietrich, S.; Manios, Y.; Grammatikaki, E.; Bouloubasi, Z.; Cook, T. L.; Eleutheriou, S.; Consta, O.; Moschonis, G.; Katsaroli, I.; Kraniou, G.; Papoutsou, S.; Keke, D.; Petraki, I.; Bellou, E.; Tanagra, S.; Kallianoti, K.; Argyropoulou, D.; Tsikrika, S.; Karaiskos, C.; Meirhaeghe, A.; Meirhaeghe, A.; Ortega, F. B.; Hagströmer, M.; Wennlöf, A. H.; Hallström, L.; Patterson, E.; Kwak, L.; Rizzo, N.; Sánchez-Molero, J.; Picó, E.; Navarro, M.; Viadel, B.; Carreres, J. E.; Merino, G.; Sanjuán, R.; Lorente, M.; Sánchez, M. J.; Thomas, S.; Allchurch, E.; Burgess, P.; Astrom, A.; Sverkén, A.; Broberg, A.; Masson, A.; Lehoux, C.; Brabant, P.; Pate, P.; Fontaine, L.; Sebok, A.; Kuti, T.; Hegyi, A.; Maldonado, C.; Llorente, A.; García, E.; Von Fircks, H.; Hallberg, M. L.; Messerer, M.; Larsson, M.; Fredriksson, H.; Adamsson, V.; Börjesson, I.; Fernández, L.; Smillie, L.; Wills, J.; Pedrero-Chamizo, R.; Meléndez, A.; Valtueña, J.; Albers, U.; Benito, P. J.; Gómez Lorente, J. J.; Cañada, D.; Urzanqui, A.; Torres, R. M.; Navarro, P.

doi:10.1016/j.numecd.2017.10.004

Background and aims: Inflammation may influence the cardio-metabolic profile which relates with the risk of chronic diseases. This study aimed to assess the inflammatory status by metabolic health (MH)/body mass index (BMI) category and to assess how inflammatory markers can predict the cardio-metabolic profile in European adolescents, considering BMI. Methods and results: A total of 659 adolescents (295 boys) from a cross-sectional European study were included. Adolescents were classified by metabolic health based on age-and sex-specific cut-off points for glucose, blood pressure, triglycerides, high density cholesterol and BMI. C-reactive protein (CRP), tumor necrosis factor alpha (TNF-alpha), interleukin (IL-6), complement factors (C3, C4) and cell adhesion molecules were assessed. Results: Metabolically abnormal (MA) adolescents had higher values of C3 (p < 0.001) and C4 (p = 0.032) compared to those metabolically healthy (MHy). C3 concentrations significantly increased with the deterioration of the metabolic health and BMI (p < 0.001). Adolescents with higher values of CRP had higher probability of being in the overweight/obese-MH group than those allocated in other categories. Finally, high C3 and C4 concentrations increased the probability of having an unfavorable metabolic/BMI status. Conclusions: Metabolic/BMI status and inflammatory biomarkers are associated, being the CRP, C3 and C4 the most related inflammatory markers with this condition. C3 and C4 were associated with the cardio-metabolic health consistently.

Inflammation in metabolically healthy and metabolically abnormal adolescents: The HELENA study / González-Gil, E.M., Cadenas-Sanchez, C., Santabárbara, J., Bueno-Lozano, G., Iglesia, I., González-Gross, M., Molnar, D., Gottrand, F., De Henauw, S., Kafatos, A., Widhalm, K., Manios, Y., Siani, A., Amaro-Gahete, F., Rupérez, A.I., Cañada, D., Censi, L., Kersting, M., Dallongeville, J., Marcos, A., et al.. - In: NMCD. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES. - ISSN 0939-4753. - 28:1(2018), pp. 77-83. [10.1016/j.numecd.2017.10.004]