Safety and efficacy of eculizumab in anti-acetylcholine receptor antibody-positive refractory generalised myasthenia gravis (REGAIN): a phase 3, randomised, double-blind, placebo-controlled, multicentre study

Howard, James F;Utsugisawa, Kimiaki;Benatar, Michael;Murai, Hiroyuki;Barohn, Richard J;Illa, Isabel;Jacob, Saiju;Vissing, John;Burns, Ted M;Kissel, John T;Muppidi, Srikanth;Nowak, Richard J;O'Brien, Fanny;Wang, Jing-Jing;Mantegazza, Renato;Mazia, Claudio Gabriel;Wilken, Miguel;Ortea, Carolina;Saba, Juliet;Rugiero, Marcelo;Bettini, Mariela;Vidal, Gonzalo;Garcia, Alejandra Dalila;Lamont, Phillipa;Leong, Wai-Kuen;Boterhoven, Heidi;Fyfe, Beverly;Roberts, Leslie;Jasinarachchi, Mahi;Willlems, Natasha;Wanschitz, Julia;Löscher, Wolfgang;De Bleecker, Jan;Van den Abeele, Guy;de Koning, Kathy;De Mey, Katrien;Mercelis, Rudy;Wagemaekers, Linda;Mahieu, Delphine;Van Damme, Philip;Smetcoren, Charlotte;Stevens, Olivier;Verjans, Sarah;D'Hondt, Ann;Tilkin, Petra;Alves de Siqueira Carvalho, Alzira;Hasan, Rosa;Dias Brockhausen, Igor;Feder, David;Ambrosio, Daniel;Melo, Ana Paula;Rocha, Rosana;Rosa, Bruno;Veiga, Thabata;Augusto da Silva, Luiz;Gonçalves Geraldo, Jordana;da Penha Morita Ananias, Maria;Nogueira Coelho, Erica;Paiva, Gabriel;Pozo, Marina;Prando, Natalia;Dada Martineli Torres, Debora;Fernanda Butinhao, Cristiani;Coelho, Erica;Renata Cubas Volpe, Luciana;Duran, Gustavo;Gomes da Silva, Tamires Cristina;Otavio Maia Gonçalves, Luiz;Pazetto, Lucas Eduardo;Souza Duca, Luciana;Suriane Fialho, Tomás Augusto;Gheller Friedrich, Maurício André;Guerreiro, Alexandre;Mohr, Henrique;Pereira Martins, Maurer;da Cruz Pacheco, Daiane;Macagnan, Ana Paula;de Cassia Santos, Aline;Bulle Oliveira, Acary Souza;Amaral de Andrade, Ana Carolina;Annes, Marcelo;Cavalcante Lino, Valeria;Pinto, Wladimir;Miranda, Carolina;Carrara, Fernanda;Souza, Iandra;Genge, Angela;Massie, Rami;Campbell, Natasha;Bril, Vera;Katzberg, Hans;Soltani, Mehran;Ng, Eduardo;Siddiqi, Zaeem;Phan, Celile;Blackmore, Derrick;Vohanka, Stanislav;Bednarik, Josef;Chmelikova, Magda;Cierny, Marek;Toncrova, Stanislava;Junkerova, Jana;Kurkova, Barbora;Reguliova, Katarina;Zapletalova, Olga;Pitha, Jiri;Novakova, Iveta;Tyblova, Michaela;Wolfova, Marcela;Jurajdova, Ivana;Andersen, Henning;Harbo, Thomas;Vinge, Lotte;Mogensen, Anita;Højgaard, Joan;Witting, Nanna;Autzen, Anne Mette;Pedersen, Jane;Färkkilä, Markus;Atula, Sari;Nyrhinen, Anne;Erälinna, Juha-Pekka;Laaksonen, Mikko;Oksaranta, Olli;Eriksson, Jaana;Harrison, Tuula;Desnuelle, Claude;Sacconi, Sabrina;Soriani, Marie-Hélène;Decressac, Sonia;Moutarde, Julie;Lahaut, Pauline;Solé, Guilhem;Le Masson, Gwendal;Wielanek-Bachelet, Anne-Cécile;Gaboreau, Morgane;Moreau, Caroline;Wilson, Amy;Vial, Christophe;Bouhour, Françoise;Gervais-Bernard, Helene;Merle, Hélène;Hourquin, Caroline;Lacour, Arnaud;Outteryck, Olivier;Vermersch, Patrick;Zephir, Hélène;Millois, Edouard;Deneve, Michel;Deruelle, Fabienne;Schoser, Benedikt;Wenninger, Stephan;Stangel, Martin;Alvermann, Sascha;Gingele, Stefan;Skripuletz, Thomas;Suehs, Kurt-Wolfram;Trebst, Corinna;Fricke, Karin;Papagiannopoulos, Sotirios;Bostantzopoulou, Sevasti;Vlaikidis, Nicholas;Zampaki, Martha;Papadopoulou, Nikoletta;Mitsikostas, Dimos-Dimitrios;Kasioti, Eleni;Mitropoulou, Efstathia;Charalambous, Despoina;Rozsa, Csilla;Horvath, Melinda;Lovas, Gabor;Matolcsi, Judit;Szabo, Gyorgyi;Szabadosne, Brigitta;Vecsei, Laszlo;Dezsi, Livia;Varga, Edina;Konyane, Monika;Gross, Bella;Azrilin, Olga;Greenbereg, Nelly;Bali Kuperman, Hila;Antonini, Giovanni;Garibaldi, Matteo;Morino, Stefania;Troili, Fernanda;Di Pasquale, Antonella;Filla, Alessandro;Costabile, Teresa;Marano, Enrico;Sacca, Francesco;Marsili, Angela;Puorro, Giorgia;Maestri Tassoni, Michelangelo;De Rosa, Anna;Bonanno, Silvia;Antozzi, Carlo;Maggi, Lorenzo;Campanella, Angela;Angelini, Corrado;Cudia, Paola;Pegoraro, Valentina;Pinzan, Elena;Bevilacqua, Francesca;Orrico, Daniele;Bonifati, Domenico Marco;Evoli, Amelia;Alboini, Paolo Emilio;D'Amato, Valentina;Iorio, Raffaele;Inghilleri, Maurizio;Fionda, Laura;Frasca, Vittorio;Giacomelli, Elena;Gori, Maria;Lopergolo, Diego;Onesti, Emanuela;Gabriele, Maria;Patti, Francesco;Salvatore Caramma, Andrea;Messina, Silvia;Reggio, Ester;Caserta, Cinzia;Uzawa, Akiyuki;Kanai, Tetsuya;Mori, Masahiro;Kaneko, Yoko;Kanzaki, Akiko;Kobayashi, Eri;Masaki, Katsuhisa;Matsuse, Dai;Matsushita, Takuya;Uehara, Taira;Shimpo, Misa;Jingu, Maki;Kikutake, Keiko;Nakamura, Yumiko;Sano, Yoshiko;Nagane, Yuriko;Kamegamori, Ikuko;Fujii, Yuko;Futono, Kazumi;Tsuda, Tomoko;Saito, Yuka;Suzuki, Hidekazu;Morikawa, Miyuki;Samukawa, Makoto;Kamakura, Sachiko;Shiraishi, Hirokazu;Mitazaki, Teiichiro;Motomura, Masakatsu;Mukaino, Akihiro;Yoshimura, Shunsuke;Asada, Shizuka;Kobashikawa, Tomomi;Koga, Megumi;Maeda, Yasuko;Takada, Kazumi;Takada, Mihoko Takada;Yamashita, Yumi;Yoshida, Seiko;Suzuki, Yasushi;Akiyama, Tetsuya;Narikawa, Koichi;Tsukita, Kenichi;Meguro, Fumie;Fukuda, Yusuke;Sato, Miwako;Matsuo, Hidenori;Fukudome, Takayasu;Gondo, Yuichiro;Maeda, Yasuhiro;Nagaishi, Akiko;Nakane, Shunya;Okubo, Yoshinori;Okumura, Meinoshin;Funaka, Soichiro;Kawamura, Tomohiro;Makamori, Masayuki;Takahashi, Masanori;Hasuike, Tomoya;Higuchi, Eriko;Kobayashi, Hisako;Osakada, Kaori;Taichi, Namie;Tsuda, Emiko;Hayashi, Takashi;Hisahara, Shin;Imai, Tomihiro;Kawamata, Jun;Murahara, Takashi;Saitoh, Masaki;Shimohama, Shun;Suzuki, Shuichiro;Yamamoto, Daisuke;Konno, Shingo;Imamura, Tomomi;Inoue, Masashi;Murata, Mayumi;Nakazora, Hiroshi;Nakayama, Ritsu;Ikeda, Yasuko;Ogawa, Miki;Shirane, Maoko;Kanda, Takashi;Kawai, Motoharu;Koga, Michiaki;Ogasawara, Junichi;Omoto, Masatoshi;Sano, Yasuteru;Arima, Hideki;Fukui, Sachie;Shimose, Shigemi;Shinozaki, Hirokazu;Watanabe, Masanori;Yoshikawa, Chieko;van der Kooi, Anneke;de Visser, Marianne;Gibson, Tamar;Maessen, Jos;de Baets, Marc;Faber, Catherine;Keijzers, Maria Johanna;Miesen, Monique;Kostera-Pruszczyk, Anna;Kaminska, Anna;Kim, Byung-Jo;Lee, Chang Nyoung;Koo, Yong Seo;Seok, Hung Youl;Kang, Hoo Nam;Ra, HyeJin;Kim, Byoung Joon;Cho, Eun Bin;Lee, HyeLim;Min, Ju-Hong;Seok, Jinmyoung;Koh, Da Yoon;Kwon, JuYoung;Lee, JiEun;Park, SangAe;Hong, Yoon-Ho;Lim, Jae-Sung;Kim, MiRi;Kim, Seung Min;Kim, Yool-hee;Lee, Hyung Seok;Shin, Ha Young;Hwang, Eun Bi;Shin, MiJu;Sazonov, Denis;Yarmoschuk, Asya;Babenko, Larisa;Malkova, Nadezhda;Melnikova, Anna;Korobko, Denis;Kosykh, Evgeniya;Pokhabov, Dmitry;Nesterova, Yulia;Abramov, Vladislav;Balyazin, Victor;Casasnovas Pons, Carlos;Alberti Aguilo, Maria;Homedes-Pedret, Christian;Palacios, Natalia Julia;Lazaro, Ana;Diez Tejedor, Exuperio;Fernandez-Fournier, Mireya;Lopez Ruiz, Pedro;Rodriguez de Rivera, Francisco Javier;Salvado Figueras, Maria;Gamez, Josep;Salvado, Maria;Cortes Vicente, Elena;Diaz-Manera, Jordi;Querol Gutierrez, Luis;Rojas Garcia, Ricardo;Vidal, Nuria;Arribas-Ibar, Elisabet;Piehl, Fredrik;Hietala, Albert;Bjarbo, Lena;Lindberg, Christopher;Jons, Daniel;Andersson, Blanka;Sengun, Ihsan;Ozcelik, Pinar;Tuga, Celal;Ugur, Muzeyyen;Boz, Cavit;Altiparmak, Didem;Gazioglu, Sibel;Ozen Aydin, Cigdem;Erdem-Ozdamar, Sevim;Bekircan-Kurt, Can Ebru;Yilmaz, Ezgi;Acar, Nazire Pinar;Caliskan, Yagmur;Efendi, Husnu;Aydinlik, Seda;Cavus, Hakan;Semiz, Cansu;Tun, Ozlem;Terzi, Murat;Dogan, Baki;Onar, Musa Kazim;Sen, Sedat;Cavdar, Tugce Kirbas;Norwood, Fiona;Dimitriou, Aikaterini;Gollogly, Jakit;Mahdi-Rogers, Mohamed;Seddigh, Arshira;Maier, Gal;Sohail, Faisal;Sathasivam, Sivakumar;Arndt, Heike;Davies, Debbie;Watling, Dave;Rivner, Michael;Hartmann, J. Edward;Quarles, Brandy;Smalley, Nicole;Amato, Anthony;Cochrane, Thomas;Salajegheh, Mohammed;Roe, Kristen;Amato, Katherine;Toska, Shirli;Wolfe, Gil;Silvestri, Nicholas;Patrick, Kara;Zakalik, Karen;Katz, Jonathan;Miller, Robert;Engel, Marguerite;Bravver, Elena;Brooks, Benjamin;Plevka, Sarah;Burdette, Maryanne;Sanjak, Mohammad;Kramer, Megan;Nemeth, Joanne;Schommer, Clara;Juel, Vern;Guptill, Jeffrey;Hobson-Webb, Lisa;Beck, Kate;Carnes, Donna;Loor, John;Anderson, Amanda;Lange, Dale;Agopian, Eliz;Goldstein, Jonathan;Manning, Erin;Kaplan, Lindsay;Holzberg, Shara;Kassebaum, Nicole;Pascuzzi, Robert;Bodkin, Cynthia;Kincaid, John;Snook, Riley;Guinrich, Sandra;Micheels, Angela;Chaudhry, Vinay;Corse, Andrea;Mosmiller, Betsy;Ho, Doreen;Srinivasan, Jayashri;Vytopil, Michael;Ventura, Nicholas;Scala, Stephanie;Carter, Cynthia;Donahue, Craig;Herbert, Carol;Weiner, Elaine;McKinnon, Jonathan;Haar, Laura;McKinnon, Naya;Alcon, Karan;Daniels, Kevin;Sattar, Nadia;Jeffery, Dennis;McKenna, Kaitlyn;Guidon, Amanda;David, William;Dheel, Christina;Levine-Weinberg, Mark;Nigro, Catherine;Simpson, Ericka;Appel, Stanley H;Lai, Eugene;Lay, Luis;Pleitez, Milvia;Halton, Sharon;Faigle, Casey;Thompson, Lisa;Sivak, Mark;Shin, Susan;Bratton, Joan;Jacobs, Daniel;Brown, Gavin;Bandukwala, Ibrez;Brown, Morris;Kane, Jennifer;Blount, Ira;Freimer, Miriam;Hoyle, J. Chad;Agriesti, Julie;Khoury, Julie;Marburger, Tessa;Kaur, Harpreet;Dimitrova, Diana;Mellion, Michelle;Sachs, George;Crabtree, Brigid;Keo, Roseann;Perez, Ele Kim;Taber, Sandra;Gilchrist, James;Andoin, Angela;Darnell, Taylor;Goyal, Neelam;Sakamuri, Sarada;So, Yuen T;Welsh, Lesly Welsh;Bhavaraju-Sanka, Ratna;Tobon Gonzalez, Alejandro;Jones, Floyd;Saklad, Amy;Nations, Sharon;Trivedi, Jaya;Hopkins, Steve;Kazamel, Mohamed;Alsharabati, Mohammad;Lu, Liang;Mumfrey-Thomas, Sandi;Woodall, Amy;Richman, David;Butters, Janelle;Lindsay, Molly;Mozaffar, Tahseen;Cash, Tiyonnoh;Goyal, Namita;Roy, Gulmohor;Mathew, Veena;Maqsood, Fatima;Minton, Brian;Jones, H. James;Rosenfeld, Jeffrey;Garcia, Rebekah;Garcia, Sonia;Echevarria, Laura;Pulley, Michael;Aranke, Shachie;Berger, Alan Ross;Shah, Jaimin;Shabbir, Yasmeen;Smith, Lisa;Varghese, Mary;Gutmann, Laurie;Gutmann, Ludwig;Swenson, Andrea;Olalde, Heena;Hafer-Macko, Charlene;Kwan, Justin;Zilliox, Lindsay;Callison, Karen;DiSanzo, Beth;Naunton, Kerry;Bilsker, Martin;Sharma, Khema;Reyes, Eliana;Cooley, Anne;Michon, Sara-Claude;Steele, Julie;Karam, Chafic Karam;Chopra, Manisha;Bird, Shawn;Kaufman, Jacob;Gallatti, Nichole;Vu, Tuan;Katzin, Lara;McClain, Terry;Harvey, Brittany;Hart, Adam;Huynh, Kristin;Beydoun, Said;Chilingaryan, Amaiak;Droker, Brian;Lin, Frank;Shah, Akshay;Tran, Anh;Akhter, Salma;Malekniazi, Ali;Tandan, Rup;Hehir, Michael;Waheed, Waqar;Lucy, Shannon;Weiss, Michael;Distad, Jane;Downing, Sharon;Strom, Susan;Lisak, Robert;Bernitsas, Evanthia;Khan, Omar;Kumar Sriwastava, Shitiz;Tselis, Alexandros;Jia, Kelly;Bertorini, Tulio;Arnold, Thomas;Henderson, Kendrick;Pillai, Rekha;Liu, Ye;Wheeler, Lauren;Hewlett, Jasmine;Vanderhook, Mollie;Dicapua, Daniel;Keung, Benison;Kumar, Aditya;Patwa, Huned;Robeson, Kimberly;Nye, Joan;Vu, Hong

2017