Neurodegeneration with brain iron accumulation (NBIA) and Wilson's disease (WD) is considered the prototype of neurodegenerative disorders characterised by the overloading of iron and copper in the central nervous system. Growing evidence has unveiled the involvement of these metals in brain cortical neurotransmission. Aim of this study was to assess cortical excitability profile due to copper and iron overload.
Different cortical excitability profiles in hereditary brain iron and copper accumulation / Dubbioso, Raffaele; Ruggiero, L; Esposito, M; Tarantino, Paola; DE ANGELIS, Marcello; Aruta, Francesco; Pappata', Sabina; Ugga, Lorenzo; Piperno, Aldo; Iorio, Raffaele; Santoro, Lucio; Iodice, Rosa; Manganelli, Fiore. - In: NEUROLOGICAL SCIENCES. - ISSN 1590-1874. - 41:(2020), pp. 679-685. [10.1007/s10072-019-04147-0]
Different cortical excitability profiles in hereditary brain iron and copper accumulation
Dubbioso;L Ruggiero;M Esposito;Tarantino;Marcello De;Aruta Francesco;Pappatà Sabina;Ugga;Piperno;Iorio Raffaele;Santoro;iodic;Manganelli
2020
Abstract
Neurodegeneration with brain iron accumulation (NBIA) and Wilson's disease (WD) is considered the prototype of neurodegenerative disorders characterised by the overloading of iron and copper in the central nervous system. Growing evidence has unveiled the involvement of these metals in brain cortical neurotransmission. Aim of this study was to assess cortical excitability profile due to copper and iron overload.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
