Among the various drug discovery methods, a very promising modern approach consists in designing multi-target-directed ligands (MTDLs) able to modulate multiple targets of interest, including the pathways where hydrogen sulfide (H2S) is involved. By incorporating an H2S donor moiety into a native drug, researchers have been able to simultaneously target multiple therapeutic pathways, resulting in improved treatment outcomes. This review gives the reader some pills of successful multi-target H2S-donating molecules as worthwhile tools to combat the multifactorial nature of complex disorders, such as inflammatory-based diseases and cancer, as well as cardiovascular, metabolic, and neurodegenerative disorders.
Pills of Multi-Target H2S Donating Molecules for Complex Diseases / Corvino, Angela; Scognamiglio, Antonia; Fiorino, Ferdinando; Perissutti, Elisa; Santagada, Vincenzo; Caliendo, Giuseppe; Severino, Beatrice. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1422-0067. - 25:13(2024). [10.3390/ijms25137014]
Pills of Multi-Target H2S Donating Molecules for Complex Diseases
Corvino, Angela
Primo
;Scognamiglio, Antonia;Fiorino, Ferdinando;Perissutti, Elisa;Santagada, Vincenzo;Caliendo, Giuseppe;Severino, BeatriceUltimo
2024
Abstract
Among the various drug discovery methods, a very promising modern approach consists in designing multi-target-directed ligands (MTDLs) able to modulate multiple targets of interest, including the pathways where hydrogen sulfide (H2S) is involved. By incorporating an H2S donor moiety into a native drug, researchers have been able to simultaneously target multiple therapeutic pathways, resulting in improved treatment outcomes. This review gives the reader some pills of successful multi-target H2S-donating molecules as worthwhile tools to combat the multifactorial nature of complex disorders, such as inflammatory-based diseases and cancer, as well as cardiovascular, metabolic, and neurodegenerative disorders.File | Dimensione | Formato | |
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