IRIS
LAVECCHIA, ANTONIO
 Distribuzione geografica
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Continente #
NA - Nord America 3.967
EU - Europa 3.874
AS - Asia 2.075
AF - Africa 79
SA - Sud America 29
OC - Oceania 8
Continente sconosciuto - Info sul continente non disponibili 3
Totale 10.035
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Nazione #
US - Stati Uniti d'America 3.867
IT - Italia 2.069
SG - Singapore 642
CN - Cina 607
HK - Hong Kong 449
NL - Olanda 348
UA - Ucraina 329
IE - Irlanda 258
DE - Germania 256
FI - Finlandia 220
IN - India 119
GB - Regno Unito 100
CA - Canada 90
SE - Svezia 81
TR - Turchia 57
RU - Federazione Russa 50
FR - Francia 47
VN - Vietnam 47
CI - Costa d'Avorio 37
JP - Giappone 32
KR - Corea 24
ES - Italia 23
TW - Taiwan 21
BR - Brasile 14
CZ - Repubblica Ceca 14
ID - Indonesia 14
IR - Iran 14
LU - Lussemburgo 14
PK - Pakistan 13
CH - Svizzera 11
PH - Filippine 9
MX - Messico 8
NG - Nigeria 8
RO - Romania 8
ZA - Sudafrica 8
BE - Belgio 7
DZ - Algeria 7
GR - Grecia 6
MA - Marocco 6
PE - Perù 6
AL - Albania 5
TH - Thailandia 5
AU - Australia 4
DK - Danimarca 4
EG - Egitto 4
PL - Polonia 4
CO - Colombia 3
ET - Etiopia 3
EU - Europa 3
HU - Ungheria 3
IQ - Iraq 3
JO - Giordania 3
KE - Kenya 3
LK - Sri Lanka 3
RS - Serbia 3
AR - Argentina 2
AT - Austria 2
AZ - Azerbaigian 2
BY - Bielorussia 2
CL - Cile 2
CU - Cuba 2
EC - Ecuador 2
FJ - Figi 2
GI - Gibilterra 2
IL - Israele 2
KZ - Kazakistan 2
LV - Lettonia 2
NP - Nepal 2
NZ - Nuova Zelanda 2
SA - Arabia Saudita 2
TZ - Tanzania 2
BD - Bangladesh 1
HR - Croazia 1
LS - Lesotho 1
LT - Lituania 1
MD - Moldavia 1
MO - Macao, regione amministrativa speciale della Cina 1
MT - Malta 1
NO - Norvegia 1
PS - Palestinian Territory 1
PT - Portogallo 1
Totale 10.035
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Città #
Chandler 617
Singapore 539
Hong Kong 436
Jacksonville 311
Amsterdam 298
Santa Clara 201
Millbury 195
Naples 192
Princeton 184
Napoli 180
Nanjing 140
Boston 134
Ashburn 127
Ann Arbor 124
Wilmington 105
Beijing 102
Rome 93
Houston 83
Woodbridge 82
Milan 66
Redwood City 61
Des Moines 57
Ottawa 54
Boardman 44
Munich 43
Helsinki 41
Kronberg 38
Salerno 38
Nanchang 35
Shenyang 35
Hebei 28
Dong Ket 26
Falls Church 26
Lawrence 23
Catania 22
Changsha 21
Jiaxing 21
Dublin 19
Norwalk 18
Toronto 18
Bari 17
Hanoi 17
Shanghai 17
Tianjin 17
London 16
Taipei 16
Wuhan 16
Bologna 15
Florence 15
Seattle 15
Istanbul 14
Cagliari 13
Moscow 13
Turin 13
Pune 12
Genoa 11
Indiana 11
Kunming 11
Orange 11
Palermo 10
Siano 10
Tokyo 10
Washington 10
Casoria 9
Columbus 9
Dallas 9
Delhi 9
Frankfurt am Main 9
Guangzhou 9
Padova 9
Pisa 9
Zhengzhou 9
Bengaluru 8
Chennai 8
Fairfield 8
Jakarta 8
Brno 7
Caserta 7
Chongqing 7
Falkenstein 7
Los Angeles 7
Mountain View 7
Perugia 7
Siena 7
Bergamo 6
Busto Arsizio 6
Camerino 6
Chengdu 6
Hangzhou 6
Indianapolis 6
Johannesburg 6
Pontedera 6
Çanakkale 6
Afyonkarahisar 5
Capannori 5
Chicago 5
Compton 5
Gangnam-gu 5
Indore 5
Lima 5
Totale 5.445
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Nome #
Progettazione ed identificazione, mediante metodi computazionali integrati, di nuovi inibitori delle fosfatasi Cdc25 e della tubulina quali agenti anticancro 893
Machine-learning approaches in drug discovery: methods and applications 809
Inibitori di proteine di prenilazione come agenti antitumorali: processo di preparazione ed impieghi in campo medico. 434
Progettazione, Sintesi e Valutazione Biologica di Nuovi Ligandi del Recettore Nucleare PPAR gamma con Proprietà Antiproliferative e Pro-apoptotiche 219
Modello strutturale del dominio transmembrana del recettore oppioide kappa e relativi binding modes di ligandi benzomorfanici ed arilacetamidici kappa-selettivi 142
Discovery of new small molecules inhibiting 67 kDa laminin receptor interaction with laminin and cancer cell invasion 121
Urokinase-type plasminogen activator receptor (uPAR) expression enhances invasion and metastasis in RAS mutated tumors 95
5'-C-ethyl-tetrazolyl-N 6-substituted adenosine and 2-chloro-adenosine derivatives as highly potent dual acting A1 adenosine receptor agonists and A3 adenosine receptor antagonists 91
" Molecular Modelingof the Urotensin-II receptor Complex" 87
Adenosine signalling mediates the anti-inflammatory effects of the COX-2 inhibitor nimesulide 83
[1,2,4]Triazino[4,3-a]benzimidazole Acetic Acid Derivatives: a New Series of Selective Aldose Reductase Inhibitors 78
The 37/67kDa laminin receptor (LR) inhibitor, NSC47924, affects 37/67kDa LR cell surface localization and interaction with the cellular prion protein 77
Antitumor agents. 5. synthesis, structure-activity relationships, and biological evaluation of dimethyl-5H-pyridophenoxazin-5-ones, tetrahydro-5h-benzopyridophenoxazin-5-ones, and 5h-benzopyridophenoxazin-5-ones with potent antiproliferative activity 76
Progettazione e Sintesi di Nuovi Farmaci Antitumorali: Intercalanti del DNA ed Inibitori della Farnesiltransferasi 76
Antagonizing S1P3 receptor with cell-penetrating pepducins in skeletal muscle fibrosis 76
Activation of Non-Canonical Autophagic Pathway through Inhibition of Non-Integrin Laminin Receptor in Neuronal Cells 70
Synthesis, Biological Evaluation, and Molecular Modeling of Ribose-Modified Adenosine Analogues as Adenosine Receptor Agonists 67
Design, synthesis and biological evaluation of novel N-alkyl- and N-acyl-(7-substituted-2-phenylimidazo[1,2-a][1,3,5]triazin-4-yl)amines (ITAs) as novel A1 adenosine receptor antagonists 66
43. Synthesis, Antiproliferative Activity, and Molecular Modelling of New DNA Intercalating Pyridophenoxazinone Carboxamides 65
App maturation and intracellular localization are controlled by a specific inhibitor of 37/67 kda laminin-1 receptor in neuronal cells 63
ANTITUMOR AGENTS. 1. SYNTHESIS, BIOLOGICAL EVALUATION AND MOLECULAR MODELING OF 5H-PYRIDO[3,2-A]PHENOXAZIN-5-ONE, A NEW ACTYNOMICIN D ANALOG WITH POTENT ANTIPROLIFERATIVE ACTIVITY, 62
Modeling of Cdc25B Dual Specifity Protein Phosphatase Inhibitors: Docking of Ligands and Enzymatic Inhibition Mechanism 62
Discovery of New Small Molecules Targeting the Vitronectin Binding Site of the Urokinase Receptor That Block Cancer Cell Invasion 62
67 kDa Laminin Receptor (67LR) Involvement in the Trafficking of Normal and Leukemic Hematopoietic Stem Cells; Computer-Aided Identification of a Small Inhibitory Molecule 62
A compound-based proteomic approach discloses 15-ketoatractyligenin methyl ester as a new PPARγ partial agonist with anti-proliferative ability 62
Molecular Modeling of the Urotensin-UT Receptor Complex 61
2-(Benzimidazol-2-yl)quinoxalines: a Movel Class of Selective Antagonists at Human A(1) and A(3) Adenosine Receptors Designed by 3D Database Searching. 61
Novel, Highly Potent Aldose Reductase Inhibitors: Cyano-(2-oxo-2,3-dihydroindol-3-yl)-acetic Acid Derivatives 60
Antitumor agents 6. Synthesis, structure-activity relationships, and biological evaluation of spiro[imidazolidine-4,3'-thieno[2,3-g]quinoline]-tetraones and spiro[thieno[2,3-g]quinoline-3,5'-[1,2,4]triazinane]-tetraones with potent antiproliferative activity 60
Regulation of trafficking and folding of cellular prion protein PrPC and its shadow Shadoo 59
Novel Non-Peptide Small Molecules Preventing IKKβ/NEMO Association Inhibit NF-κB Activation in LPS-Stimulated J774 Macrophages 59
Synthesis, Pharmacological Evaluation, and Molecular Modeling Studies of Novel Peptidic CAAX Analogues as Farnesyl-Protein-Transferase Inhibitors 58
On the Metabolically Active Form of Metaglidasen: Improved Synthesis and Investigation of Its Peculiar Activity on Peroxisome Proliferator-Activated Receptors and Skeletal Muscles 57
Insights into the Mechanism of Partial Agonism. Crystal Structures of the Peroxisome Proliferator-Activated Receptor Ligand-Binding Domain in the Complex with two Enantiomeric Ligands 57
Discovery of a Novel Small Molecule Inhibitor Targeting the Frataxin/Ubiquitin Interaction via Structure-Based Virtual Screening and Bioassays 57
Novel, Highly Potent Adenosine Deaminase Inhibitors Containing the Pyrazolo[3,4-d]pyrimidine Ring System. Synthesis, Structure-Activity Relationships, and Molecular Modeling Studies 56
Discovery of New Small Molecules Targeting the Vitronectin-Binding Site of the Urokinase Receptor That Block Cancer Cell Invasion 56
Cdc25 inhibitors in melanoma cells 56
Discovery of Novel Naphthylphenylketone and Naphthylphenylamine Derivatives as Cell Division Cycle 25B (CDC25B) Phosphatase Inhibitors: Design, Synthesis, Inhibition Mechanism, and in Vitro Efficacy against Melanoma Cell Lines 56
Antagonizing S1P3 receptor with Cell-Penetrating Pepducins in Skeletal Muscle Fibrosis 56
Analoghi degli acidi clofibrici e loro uso come ligandi dei recettori nucleari peroxisome proliferator activated receptor (PPAR) alpha e gamma" 55
Antitumor Agents. 4. Characterization of Free Radicals Produced During Reduction of the Antitumor Drug 5H-Pyridophenoxazin-5-one (PPH). An EPR Study. 55
3-Aryl[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-ones: A New Class of Selective A1 Adenosine Receptor Antagonists. 53
5'-Carbamoyl derivatives of 2'-C-methyl-purine nucleosides as selective A1 adenosine receptor agonists: affinity, efficacy, and selectivity for A1 receptor from different species 52
Discovery of New Inhibitors of Cdc25B Dual Specificity Phosphatases by Structure-Based Virtual Screening 52
Antitumor Agents. 1. Synthesis, Biological Evaluation and Molecular Modeling of 5H-pyrido[3,2-a]phenoxazin-5-one, a Compound with Potent Antiproliferative Activity 51
Pyrrolo[1,2-b][1,2,5]benzothiadiazepines (PBTDs): a New Class of Agents endowed with High Apoptotic Activity in Chronic Myelogenous Leukemia K562 Cells and in Cells from Patients at Onset and Imatinib-Resistant. 51
Exploring the molecular basis of the enantioselective binding of penicillin G acylase towards a series of 2-aryloxyalkanoic acids: A docking and molecular dynamics study 51
Ligand Binding Analysis for Human alfa 5 beta 1 Integrin: Strategies for Designing New alfa 5 beta 1 Integrin Antagonists 51
Ligand-based chemoinformatic discovery of a novel small molecule inhibitor targeting CDC25 dual specificity phosphatases and displaying in vitro efficacy against melanoma cells 51
Arylthioindole Inhibitors of Tubulin Polymerization. 3. Biological Evaluation, Structure-Activity Relationships and Molecular Modeling Studies 50
Amorfrutins are efficient modulators of peroxisome proliferator-activated receptor gamma (PPARγ) with potent antidiabetic and anticancer properties: A patent evaluation of WO2014177593 A1 50
Unlocking the Potential of Generative Artificial Intelligence in Drug Discovery 49
A1 adenosine receptor antagonists, 3-aryl[1,2,4]triazino[4,3-a]benzimidazol-4-(10H)-ones (ATBIs) and N-alkyl and N-acyl-(7-substituted-2-phenylimidazo[1,2-a][1,3,5]triazin-4-yl)amines (ITAs): Different recognition of bovine and human binding sites 49
Design, Synthesis, Biological Evaluation, and Molecular Modeling Studies of TIBO-Like Cyclic Sulfones as Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors 49
Characterizing the 1,4-Dihydropyridines Binding Interactions in the L-Type Ca2+ Channel: Model Construction and Docking Calculations 48
Synthesis, Biological Evaluation, and Molecular Modeling Investigation of New Chiral Fibrates with PPARα and PPARγ Agonist Activity 48
Reaction between Quinone and Thiazolidine. A Study on the Formation Mechanism of New Antiproliferative Quinolindiones 48
N-formyl peptide receptors induce radical oxygen production in fibroblasts derived from systemic sclerosis by interacting with a cleaved form of urokinase receptor 48
Solution conformation of a potent cyclic analog of Tuftsin : low temperature nuclear magnetic resonance study in a cryoprotective mixture. 47
Design, Molecular Modeling, Synthesis, and Anti-HIV-1 Activity of New Indolyl Aryl Sulfones. Novel Derivatives of the Indole-2-carboxamide 47
Novel Quinolinonyl Diketo Acid Derivatives as HIV-1 Integrase Inhibitors: Design, Synthesis, and Biological Activities 47
Discovery Of Novel Peroxisome Proliferator-Activated Receptor γ (PPARγ) Scaffolds With Partial Agonist Binding Properties By Integrated In Silico/In Vitro Work Flow 47
Docking Studies on Bifunctional Quinolinyl Diketo Acids as HIV-1 Integrase Inhibitors. 46
Modeling of k-Opioid Receptor/Agonists Interactions Using Pharmacophore-Based and Docking Simulations 46
Antitumor Agents. 2. Synthesis, Structure-Activity Relationships and Biological Evaluation of Novel 5H-pyridophenoxazin-5-ones with Potent Antiproliferative Activity 46
Elucidation of the Enantioselective Recognition Mechanism of a Penicillin G Acylase-Based Chiral Stationary Phase Towards a Series of 2-Aryloxy-2-Aryl-Acetic Acids. 46
Novel Bifunctional Quinolonyl Diketo Acid Derivatives as HIV-1 Integrase Inhibitors: Design, Synthesis, Biological Activities, and Mechanism of Action 46
Synthesis, cannabinoid receptor affinity, and molecular modeling studies of substituted 1-aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides 46
Progettazione e sintesi di nuovi farmaci antitumorali: intercalanti del Dna e inibitori delle Farnesil Trasferasi 46
In silico methods to address polypharmacology: Current status, applications and future perspectives 46
Inhibition mechanism of naphthylphenylamine derivatives acting on the CDC25B dual phosphatase and analysis of the molecular processes involved in the high cytotoxicity exerted by one selected derivative in melanoma cells 46
Computer-Aided Engineering of GPCRs and Its Application to Drug Discovery 44
Docking Studies on avb3 Integrin Ligands: Pharmacophore Refinement and Implications for Drug Design 44
Solution of a Potent Cyclic Analog of Tufsin: A Low Temperature NMR Study in a Cryoprotective Mixture 44
Synthesis, Biological Evaluation and Molecular Modeling Investigation of Chiral Phenoxyacetic Acid Analogues with PPARalfa and PPARgamma Agonist Activity 44
Arylthiopyrrole (AThP) Derivatives as Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors. Synthesis, Structure-Activity Relationships and Docking Studies. Part 2. 44
New Pyrrole Inhibitors of Monoamine Oxidase: Synthesis, Biological Evaluation and Structural Determinants of MAO-A and MAO-B Selectivity 44
Virtual Screening Strategies in Drug Discovery: a Critical Review 44
Synthesis and Structural Analysis of Cyclic Oligomers Consisting of Furanoid and Pyranoid epsilon-Sugar Amino Acids 43
Novel N-(Arylalkyl)indol-3-ylglyoxylyamides Targeted as Ligands of the Benzodiazepine Receptor: Synthesis, Biological Evaluation, and Molecular Modeling Analysis of the Structure-Activity Relationships 43
Arylthiopyrrole (AThP) Derivatives as Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors. Synthesis, Structure-Activity Relationships and Docking Studies. Part 1. 43
Syntheses, Biological Evaluation and Molecular Modeling of 18F-labeled 4-Anilidopiperidines as μ-Opioid Receptor Imaging Agents 43
The antiproliferative and proapoptotic effects of cladosporols A and B are related to their different binding mode as PPARγ ligands 43
Computer-Assisted Design, Synthesis and Biological Evaluation of Novel Pyrrolyl Heteroaryl Sulfones Targeted at HIV-1 Reverse Transcriptase as Non-Nucleoside Inhibitors. 42
Synthesis, Molecular Modeling and mu-Opioid Receptor Affinity of 9,10-Diazatricyclo[4.2.1.12,5] decanes and 2,7-Diazatricyclo[4.4.0.03,8]decanes Structurally Related to 3,8-Diazabicyclo[3.2.1]octanes 42
Naphtho[1,2-d]isothiazole Acetic Acid Derivatives as a Novel Class of Selective Aldose Reductase Inhibitors 42
Design and Synthesis of 2-Heterocyclyl-3-arylthio-1H-indoles as Potent Tubulin Polymerization and Cell Growth Inhibitors with Improved Metabolic Stability 42
Novel Highly Potent Adenosine Deaminase Inhibitors Containing the Pyrazolo[3,4-d]pyrimidine Ring System. Synthesis, Structure-Activity Relationships and Molecular Modeling Studies. 41
Architecture of the Human Urotensin II Receptor: Comparison of the Binding Domains of Peptide and Non-Peptide Urotensin II Agonists 41
Pharmacokinetic profile of atenolol aspirinate 41
Small Molecule Drugs And Targeted Therapy For Melanoma: Current Strategies And Future Directions 41
Conformational Analysis of Furanoid e-Sugar Amino Acid Containing Cyclic Peptides by NMR Spectroscopy, Molecular Dynamics Simulation, and X-ray Crystallography: Evidence for a Novel Turn Structure 40
Structure-Activity Studies of the Melanocortin Peptides: Discovery of Potent and Selective Antagonists at hMC3 and hMC4 Receptors 40
Structure-Activity Relationship Studies on Potential Non-Nucleoside DABO-like Inhibitors of HIV-1 Reverse Transcriptase 40
Molecular modeling e progettazione di inibitori dell’Integrasi, della Trascrittasi inversa e dell’interazione Tat-TAR quali agenti anti-AIDS 40
Development of Peptidomimetic Boronates as Proteasome Inhibitors 40
Enantioselective Hydrolysis of Some 2-Aryloxyalkanoic Acid Methyl Esters and Isosteric Analogs Using a Penicillin G Acylase Based HPLC Monolithic Silica Column 39
Antitumor agents 7. Synthesis, antiproliferative activity and molecular modeling of new L-lysine-conjugated pyridophenoxazinones as potent DNA-binding ligands and topoisomerase IIα inhibitors 39
Benzodiazepine Derivatives and Uses Thereof in Medical Field 38
Totale 7.601
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Categoria #
all - tutte 37.211
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 37.211
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/2020391 0 0 0 0 0 0 9 3 15 76 148 140
2020/20211.106 36 92 85 108 163 143 100 45 123 39 91 81
2021/20221.395 42 22 45 34 28 57 31 66 275 58 181 556
2022/20231.980 272 147 61 202 153 168 105 157 248 298 101 68
2023/20241.476 80 167 178 87 72 107 115 213 44 56 239 118
2024/20252.093 356 381 126 150 197 298 585 0 0 0 0 0
Totale 10.460