IRIS
LAVECCHIA, ANTONIO
 Distribuzione geografica
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Continente #
AS - Asia 8.157
EU - Europa 7.482
NA - Nord America 7.453
SA - Sud America 810
AF - Africa 231
OC - Oceania 17
Continente sconosciuto - Info sul continente non disponibili 8
Totale 24.158
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Nazione #
US - Stati Uniti d'America 7.166
SG - Singapore 3.558
IT - Italia 2.582
RU - Federazione Russa 2.127
CN - Cina 1.518
VN - Vietnam 1.214
HK - Hong Kong 699
BR - Brasile 618
DE - Germania 493
NL - Olanda 465
UA - Ucraina 357
FR - Francia 311
FI - Finlandia 292
IN - India 289
IE - Irlanda 264
GB - Regno Unito 205
JP - Giappone 175
CA - Canada 171
SE - Svezia 101
BD - Bangladesh 96
KR - Corea 89
TR - Turchia 88
MX - Messico 72
ID - Indonesia 65
AR - Argentina 62
ZA - Sudafrica 62
ES - Italia 53
PH - Filippine 44
CI - Costa d'Avorio 43
PL - Polonia 43
IQ - Iraq 42
TH - Thailandia 42
TW - Taiwan 41
PK - Pakistan 37
EC - Ecuador 29
CO - Colombia 25
LT - Lituania 23
AT - Austria 22
MA - Marocco 21
JO - Giordania 19
BE - Belgio 18
CL - Cile 18
CZ - Repubblica Ceca 18
PE - Perù 18
IR - Iran 17
NG - Nigeria 16
PY - Paraguay 16
SA - Arabia Saudita 15
VE - Venezuela 15
CH - Svizzera 14
DZ - Algeria 14
LU - Lussemburgo 14
UZ - Uzbekistan 13
NP - Nepal 12
RO - Romania 12
EG - Egitto 11
ET - Etiopia 11
KE - Kenya 11
AZ - Azerbaigian 10
TN - Tunisia 10
AU - Australia 9
PT - Portogallo 9
JM - Giamaica 8
KZ - Kazakistan 8
MY - Malesia 8
AE - Emirati Arabi Uniti 7
AL - Albania 7
IL - Israele 7
BY - Bielorussia 6
GR - Grecia 6
UY - Uruguay 6
NO - Norvegia 5
OM - Oman 5
PS - Palestinian Territory 5
RS - Serbia 5
TT - Trinidad e Tobago 5
AF - Afghanistan, Repubblica islamica di 4
DK - Danimarca 4
HU - Ungheria 4
KH - Cambogia 4
LK - Sri Lanka 4
LV - Lettonia 4
MD - Moldavia 4
BS - Bahamas 3
BW - Botswana 3
CG - Congo 3
CR - Costa Rica 3
CU - Cuba 3
DM - Dominica 3
EU - Europa 3
KG - Kirghizistan 3
LB - Libano 3
NI - Nicaragua 3
NZ - Nuova Zelanda 3
PA - Panama 3
SK - Slovacchia (Repubblica Slovacca) 3
TZ - Tanzania 3
XK - ???statistics.table.value.countryCode.XK??? 3
BB - Barbados 2
BG - Bulgaria 2
Totale 24.089
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Città #
Singapore 1.639
San Jose 1.142
Hong Kong 670
Chandler 617
Moscow 519
Ashburn 495
Beijing 379
Ho Chi Minh City 340
Jacksonville 312
Amsterdam 311
Naples 298
Hanoi 293
Santa Clara 231
Dallas 210
The Dalles 209
Hefei 208
Lauterbourg 195
Millbury 195
Princeton 184
Napoli 180
Munich 171
Boston 150
Los Angeles 145
Nanjing 140
Tokyo 138
Ann Arbor 124
Rome 114
Milan 108
Wilmington 107
Buffalo 99
Houston 98
New York 83
Woodbridge 83
Helsinki 80
São Paulo 66
Redondo Beach 63
Redwood City 61
Des Moines 57
Ottawa 56
Da Nang 50
Haiphong 49
Frankfurt am Main 47
London 47
Orem 47
Boardman 46
Seoul 43
Council Bluffs 39
Mexico City 39
Kronberg 38
Salerno 38
Chicago 36
Johannesburg 36
Toronto 36
Nanchang 35
Shenyang 35
Nuremberg 31
Phoenix 31
Chennai 30
Montreal 30
Warsaw 30
Shanghai 29
Hebei 28
Dong Ket 26
Falls Church 26
Changsha 25
Dublin 25
Atlanta 24
Denver 24
Stockholm 24
Biên Hòa 23
Brooklyn 23
Falkenstein 23
Lawrence 23
Baghdad 22
Catania 22
Jiaxing 22
Bologna 21
Florence 21
Istanbul 21
North Bergen 21
Seattle 21
Tianjin 21
Turku 21
Bari 20
Norwalk 20
Guangzhou 19
Hải Dương 19
Cagliari 18
Rio de Janeiro 18
Wuhan 18
Amman 17
Belo Horizonte 17
Mumbai 17
Taipei 17
Jakarta 16
Palermo 16
Pune 16
Bengaluru 15
Can Tho 15
Poplar 15
Totale 12.212
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Nome #
Progettazione ed identificazione, mediante metodi computazionali integrati, di nuovi inibitori delle fosfatasi Cdc25 e della tubulina quali agenti anticancro 1.178
Machine-learning approaches in drug discovery: methods and applications 1.065
Inibitori di proteine di prenilazione come agenti antitumorali: processo di preparazione ed impieghi in campo medico. 723
Progettazione, Sintesi e Valutazione Biologica di Nuovi Ligandi del Recettore Nucleare PPAR gamma con Proprietà Antiproliferative e Pro-apoptotiche 297
" Molecular Modelingof the Urotensin-II receptor Complex" 242
5'-C-ethyl-tetrazolyl-N 6-substituted adenosine and 2-chloro-adenosine derivatives as highly potent dual acting A1 adenosine receptor agonists and A3 adenosine receptor antagonists 213
Urokinase-type plasminogen activator receptor (uPAR) expression enhances invasion and metastasis in RAS mutated tumors 213
Adenosine signalling mediates the anti-inflammatory effects of the COX-2 inhibitor nimesulide 201
Modello strutturale del dominio transmembrana del recettore oppioide kappa e relativi binding modes di ligandi benzomorfanici ed arilacetamidici kappa-selettivi 198
Discovery of new small molecules inhibiting 67 kDa laminin receptor interaction with laminin and cancer cell invasion 193
Secoiridoid-enriched extra virgin olive oil extracts enhance mitochondrial activity and antioxidant response in colorectal cancer cells: The role of Oleacein and Oleocanthal in PPARγ interaction 179
Activation of Non-Canonical Autophagic Pathway through Inhibition of Non-Integrin Laminin Receptor in Neuronal Cells 179
Unlocking the Potential of Generative Artificial Intelligence in Drug Discovery 174
67 kDa Laminin Receptor (67LR) Involvement in the Trafficking of Normal and Leukemic Hematopoietic Stem Cells; Computer-Aided Identification of a Small Inhibitory Molecule 169
Antagonizing S1P3 receptor with cell-penetrating pepducins in skeletal muscle fibrosis 168
The 37/67kDa laminin receptor (LR) inhibitor, NSC47924, affects 37/67kDa LR cell surface localization and interaction with the cellular prion protein 167
Discovery of New Small Molecules Targeting the Vitronectin Binding Site of the Urokinase Receptor That Block Cancer Cell Invasion 166
Antagonizing S1P3 receptor with Cell-Penetrating Pepducins in Skeletal Muscle Fibrosis 162
N-formyl peptide receptors induce radical oxygen production in fibroblasts derived from systemic sclerosis by interacting with a cleaved form of urokinase receptor 159
Cdc25 inhibitors in melanoma cells 156
43. Synthesis, Antiproliferative Activity, and Molecular Modelling of New DNA Intercalating Pyridophenoxazinone Carboxamides 154
Novel Non-Peptide Small Molecules Preventing IKKβ/NEMO Association Inhibit NF-κB Activation in LPS-Stimulated J774 Macrophages 153
Design, synthesis and biological evaluation of novel N-alkyl- and N-acyl-(7-substituted-2-phenylimidazo[1,2-a][1,3,5]triazin-4-yl)amines (ITAs) as novel A1 adenosine receptor antagonists 151
[1,2,4]Triazino[4,3-a]benzimidazole Acetic Acid Derivatives: a New Series of Selective Aldose Reductase Inhibitors 145
Regulation of trafficking and folding of cellular prion protein PrPC and its shadow Shadoo 141
App maturation and intracellular localization are controlled by a specific inhibitor of 37/67 kda laminin-1 receptor in neuronal cells 141
Discovery of a Novel Small Molecule Inhibitor Targeting the Frataxin/Ubiquitin Interaction via Structure-Based Virtual Screening and Bioassays 140
Discovery Of Novel Peroxisome Proliferator-Activated Receptor γ (PPARγ) Scaffolds With Partial Agonist Binding Properties By Integrated In Silico/In Vitro Work Flow 139
Ligand-based chemoinformatic discovery of a novel small molecule inhibitor targeting CDC25 dual specificity phosphatases and displaying in vitro efficacy against melanoma cells 137
Progettazione e Sintesi di Nuovi Farmaci Antitumorali: Intercalanti del DNA ed Inibitori della Farnesiltransferasi 136
A compound-based proteomic approach discloses 15-ketoatractyligenin methyl ester as a new PPARγ partial agonist with anti-proliferative ability 135
Discovery of Novel Naphthylphenylketone and Naphthylphenylamine Derivatives as Cell Division Cycle 25B (CDC25B) Phosphatase Inhibitors: Design, Synthesis, Inhibition Mechanism, and in Vitro Efficacy against Melanoma Cell Lines 135
Discovery of New Inhibitors of Cdc25B Dual Specificity Phosphatases by Structure-Based Virtual Screening 133
Novel Reversible Inhibitors of Xanthine Oxidase Targeting the Active Site of the Enzyme 131
Development of novel pseudopeptides targeting the 20s proteasome as anticancer agents 131
Synthesis, Pharmacological Evaluation, and Molecular Modeling Studies of Novel Peptidic CAAX Analogues as Farnesyl-Protein-Transferase Inhibitors 130
Inhibition mechanism of naphthylphenylamine derivatives acting on the CDC25B dual phosphatase and analysis of the molecular processes involved in the high cytotoxicity exerted by one selected derivative in melanoma cells 129
Antitumor Agents. 4. Characterization of Free Radicals Produced During Reduction of the Antitumor Drug 5H-Pyridophenoxazin-5-one (PPH). An EPR Study. 127
Novel Quinolinonyl Diketo Acid Derivatives as HIV-1 Integrase Inhibitors: Design, Synthesis, and Biological Activities 126
Inhibition of 37/67kDa laminin-1 receptor restores APP maturation and reduces Amyloid- in human skin fibroblasts from familial Alzheimer’s disease 126
Antitumor agents. 5. synthesis, structure-activity relationships, and biological evaluation of dimethyl-5H-pyridophenoxazin-5-ones, tetrahydro-5h-benzopyridophenoxazin-5-ones, and 5h-benzopyridophenoxazin-5-ones with potent antiproliferative activity 124
Modeling of Cdc25B Dual Specifity Protein Phosphatase Inhibitors: Docking of Ligands and Enzymatic Inhibition Mechanism 124
Discovery of New Small Molecules Targeting the Vitronectin-Binding Site of the Urokinase Receptor That Block Cancer Cell Invasion 121
Targeting RPSA to modulate endosomal trafficking and amyloidogenesis in genetic Alzheimer's disease 120
In Silico Identification of Novel Inhibitors Targeting the Homodimeric Interface of Superoxide Dismutase from the Dental Pathogen Streptococcus mutans 120
CDC25A and B Dual-Specificity Phosphatase Inhibitors: Potential Agents for Cancer Therapy 120
Analoghi degli acidi clofibrici e loro uso come ligandi dei recettori nucleari peroxisome proliferator activated receptor (PPAR) alpha e gamma" 119
Identification of a new series of non-covalent proteasome inhibitors with selectivity for β5-subunits 117
Characterization of novel inhibitors of CDC25 phosphatases: biochemical and biological analysis 117
The Structure of The Laminin Β1 Nonapeptide Probed Through Long-Timescale Temperature Replica-Exchange Molecular Dynamics Simulations in Explicit Solvent 116
The antiproliferative and proapoptotic effects of cladosporols A and B are related to their different binding mode as PPARγ ligands 116
Development of Novel Selective Peptidomimetics Containing a Boronic Acid Moiety, Targeting the 20S Proteasome as Anticancer Agents 115
Identification of selective 5-LOX and FLAP inhibitors as novel anti-inflammatory agents by ligand-based virtual screening 114
Novel Highly Potent Adenosine Deaminase Inhibitors Containing the Pyrazolo[3,4-d]pyrimidine Ring System. Synthesis, Structure-Activity Relationships and Molecular Modeling Studies. 114
The Crosstalk between N-Formyl Peptide Receptors and uPAR in Systemic Sclerosis: Molecular Mechanisms, Pathogenetic Role and Therapeutic Opportunities 113
Solution conformation of a potent cyclic analog of Tuftsin : low temperature nuclear magnetic resonance study in a cryoprotective mixture. 113
Novel N-(Arylalkyl)indol-3-ylglyoxylyamides Targeted as Ligands of the Benzodiazepine Receptor: Synthesis, Biological Evaluation, and Molecular Modeling Analysis of the Structure-Activity Relationships 113
Antitumor agents 7. Synthesis, antiproliferative activity and molecular modeling of new L-lysine-conjugated pyridophenoxazinones as potent DNA-binding ligands and topoisomerase IIα inhibitors 113
Development of Peptidomimetic Boronates as Proteasome Inhibitors 112
ANTITUMOR AGENTS. 1. SYNTHESIS, BIOLOGICAL EVALUATION AND MOLECULAR MODELING OF 5H-PYRIDO[3,2-A]PHENOXAZIN-5-ONE, A NEW ACTYNOMICIN D ANALOG WITH POTENT ANTIPROLIFERATIVE ACTIVITY, 110
Novel, Highly Potent Aldose Reductase Inhibitors: Cyano-(2-oxo-2,3-dihydroindol-3-yl)-acetic Acid Derivatives 110
Synthesis, Biological Evaluation, and Molecular Modeling of Ribose-Modified Adenosine Analogues as Adenosine Receptor Agonists 110
Antitumor agents 6. Synthesis, structure-activity relationships, and biological evaluation of spiro[imidazolidine-4,3'-thieno[2,3-g]quinoline]-tetraones and spiro[thieno[2,3-g]quinoline-3,5'-[1,2,4]triazinane]-tetraones with potent antiproliferative activity 110
Identification of a new series of amides as non-covalent proteasome inhibitors 109
3-Aryl[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-ones: A New Class of Selective A1 Adenosine Receptor Antagonists. 108
Small Molecule Drugs And Targeted Therapy For Melanoma: Current Strategies And Future Directions 108
Progettazione e sintesi di nuovi farmaci antitumorali: intercalanti del Dna e inibitori delle Farnesil Trasferasi 106
Synthesis, characterization and biological evaluation of ureidofibrate-like derivatives endowed with peroxisome proliferator-activated receptor activity 106
2-(Benzimidazol-2-yl)quinoxalines: a Movel Class of Selective Antagonists at Human A(1) and A(3) Adenosine Receptors Designed by 3D Database Searching. 105
CDC25 Phosphatase Inhibitors: An Update 105
Development of Peptidomimetic Boronates as Proteasome Inhibitors 105
Synthesis and in vitro cytotoxicity of benzoxazole‐based PPARα/γ antagonists in colorectal cancer cell lines 104
Benzodiazepine Derivatives and Uses Thereof in Medical Field 104
Sulfonimide and amide derivatives as novel PPARα antagonists: Synthesis, antiproliferative activity, and docking studies 104
Development of novel amides as noncovalent inhibitors of immunoproteasomes 102
Deep generative models in the quest for anticancer drugs: ways forward 101
Sintesi ed Attività Biologica di Acidi Idrossichinolinon e Idrossichinolinchinon Carbossilici con Potente Attività Antiproliferativa. 101
New diphenylmethane derivatives as peroxisome proliferator-activated receptor alpha/gamma dual agonists endowed with anti-proliferative effects and mitochondrial activity 101
Docking Studies on Bifunctional Quinolinyl Diketo Acids as HIV-1 Integrase Inhibitors. 100
Exploring structural relationships between bioactive and commercial chemical space and developing target hypotheses for compound acquisition 99
On the Metabolically Active Form of Metaglidasen: Improved Synthesis and Investigation of Its Peculiar Activity on Peroxisome Proliferator-Activated Receptors and Skeletal Muscles 98
Chiral phenoxyacetic acid analogues inhibit colon cancer cell proliferation acting as PPARγ partial agonists 98
Synthesis and Conformational Studies of Cyclic Peptides with Antagonist Activity at Melanocortin 3 and 4 Receptors 97
Identification of chemically diverse Cdc25 phosphatase inhibitors by receptor-based virtual screening 97
Novel inhibitors of signal transducer and activator of transcription 3 signaling pathway: an update on the recent patent literature 97
Design, Synthesis And Biological Evaluation of New Analogs of The Dual PPARα/γ Agonist Lt175 97
5'-Carbamoyl derivatives of 2'-C-methyl-purine nucleosides as selective A1 adenosine receptor agonists: affinity, efficacy, and selectivity for A1 receptor from different species 96
A chemical modification of a peroxisome proliferator-activated receptor pan agonist produced a shift to a new dual alpha/gamma partial agonist endowed with mitochondrial pyruvate carrier inhibition and antidiabetic properties 95
Design and Synthesis of 2-Heterocyclyl-3-arylthio-1H-indoles as Potent Tubulin Polymerization and Cell Growth Inhibitors with Improved Metabolic Stability 95
Diarylheterocycle Core Ring Features Effect in Selective COX-1 Inhibition 95
Molecular Modeling of the Urotensin-UT Receptor Complex 94
Synthesis, Molecular Modeling and mu-Opioid Receptor Affinity of 9,10-Diazatricyclo[4.2.1.12,5] decanes and 2,7-Diazatricyclo[4.4.0.03,8]decanes Structurally Related to 3,8-Diazabicyclo[3.2.1]octanes 94
New 2-(aryloxy)-3-phenylpropanoic acids as peroxisome proliferator-activated receptor α/γ dual agonists able to upregulate mitochondrial carnitine shuttle system gene expression 94
Arylthioindole Inhibitors of Tubulin Polymerization. 3. Biological Evaluation, Structure-Activity Relationships and Molecular Modeling Studies 91
Synthesis, biological evaluation and molecular investigation of fluorinated peroxisomes proliferator-activated receptors α/γ dual agonists 91
Characterization of two synthetic ligands of peroxisomeproliferator-activated receptor γ (PPARγ) by cofactorrecruitment, site-directed mutagenesis and structure analysis 91
Modeling of k-Opioid Receptor/Agonists Interactions Using Pharmacophore-Based and Docking Simulations 90
Conformational Analysis of Furanoid e-Sugar Amino Acid Containing Cyclic Peptides by NMR Spectroscopy, Molecular Dynamics Simulation, and X-ray Crystallography: Evidence for a Novel Turn Structure 90
Antitumor Agents. 1. Synthesis, Biological Evaluation and Molecular Modeling of 5H-pyrido[3,2-a]phenoxazin-5-one, a Compound with Potent Antiproliferative Activity 90
Molecular modeling e progettazione di inibitori dell’Integrasi, della Trascrittasi inversa e dell’interazione Tat-TAR quali agenti anti-AIDS 90
Totale 15.251
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Categoria #
all - tutte 71.582
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 71.582
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/202181 0 0 0 0 0 0 0 0 0 0 0 81
2021/20221.395 42 22 45 34 28 57 31 66 275 58 181 556
2022/20231.980 272 147 61 202 153 168 105 157 248 298 101 68
2023/20241.476 80 167 178 87 72 107 115 213 44 56 239 118
2024/20256.014 356 381 126 150 197 298 772 414 500 486 1.821 513
2025/202610.254 1.168 784 1.091 846 1.773 479 1.191 638 1.224 624 393 43
Totale 24.635