IRIS
SANTORO, MASSIMO
 Distribuzione geografica
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Continente #
AS - Asia 10.015
NA - Nord America 8.957
EU - Europa 7.170
SA - Sud America 1.353
AF - Africa 253
OC - Oceania 11
Continente sconosciuto - Info sul continente non disponibili 4
Totale 27.763
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Nazione #
US - Stati Uniti d'America 8.621
SG - Singapore 4.706
RU - Federazione Russa 2.873
CN - Cina 1.704
VN - Vietnam 1.700
IT - Italia 1.309
BR - Brasile 1.087
HK - Hong Kong 985
DE - Germania 548
UA - Ucraina 419
FI - Finlandia 393
IE - Irlanda 380
FR - Francia 371
SE - Svezia 277
GB - Regno Unito 197
CA - Canada 194
NL - Olanda 178
IN - India 177
JP - Giappone 176
AR - Argentina 97
BD - Bangladesh 95
IQ - Iraq 74
MX - Messico 74
ZA - Sudafrica 74
ES - Italia 53
CI - Costa d'Avorio 50
PH - Filippine 50
PL - Polonia 47
EC - Ecuador 45
TH - Thailandia 43
TR - Turchia 37
KR - Corea 35
ID - Indonesia 32
VE - Venezuela 32
PK - Pakistan 28
AT - Austria 27
CO - Colombia 27
PY - Paraguay 22
KE - Kenya 18
MA - Marocco 17
TW - Taiwan 17
CL - Cile 16
LT - Lituania 16
SA - Arabia Saudita 15
UZ - Uzbekistan 15
AE - Emirati Arabi Uniti 13
AZ - Azerbaigian 13
DZ - Algeria 13
IL - Israele 12
TN - Tunisia 12
CZ - Repubblica Ceca 11
PE - Perù 11
IR - Iran 10
JO - Giordania 10
NP - Nepal 10
AL - Albania 9
EG - Egitto 9
UY - Uruguay 9
CR - Costa Rica 8
JM - Giamaica 8
NI - Nicaragua 8
BE - Belgio 7
DO - Repubblica Dominicana 7
HN - Honduras 7
PA - Panama 7
BG - Bulgaria 6
ET - Etiopia 6
GE - Georgia 6
PT - Portogallo 6
SN - Senegal 6
AO - Angola 5
AU - Australia 5
BO - Bolivia 5
GT - Guatemala 5
LB - Libano 5
LY - Libia 5
NG - Nigeria 5
PS - Palestinian Territory 5
RO - Romania 5
BA - Bosnia-Erzegovina 4
CH - Svizzera 4
KG - Kirghizistan 4
KZ - Kazakistan 4
OM - Oman 4
TT - Trinidad e Tobago 4
BB - Barbados 3
BH - Bahrain 3
GR - Grecia 3
HR - Croazia 3
HU - Ungheria 3
MD - Moldavia 3
MY - Malesia 3
NC - Nuova Caledonia 3
PR - Porto Rico 3
RS - Serbia 3
SK - Slovacchia (Repubblica Slovacca) 3
SY - Repubblica araba siriana 3
TJ - Tagikistan 3
YT - Mayotte 3
BJ - Benin 2
Totale 27.688
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Città #
Singapore 2.008
San Jose 1.312
Hong Kong 948
Chandler 762
Moscow 758
Ashburn 527
Jacksonville 492
Ho Chi Minh City 475
Beijing 424
Hanoi 414
Naples 350
Millbury 344
Princeton 323
Santa Clara 298
Lauterbourg 288
The Dalles 277
Nanjing 248
Los Angeles 236
Woodbridge 213
Amsterdam 152
Wilmington 150
Napoli 145
Tokyo 144
Buffalo 139
Boston 137
Munich 126
São Paulo 101
Nanchang 98
Ottawa 92
New York 88
Haiphong 87
Houston 85
Redondo Beach 78
Hamburg 73
Hefei 70
Dallas 68
Ann Arbor 66
Da Nang 64
Shenyang 55
Orem 50
Kronberg 49
Seattle 49
Brooklyn 48
Tianjin 46
Chicago 45
Hebei 44
Frankfurt am Main 43
Warsaw 43
Norwalk 42
Rome 42
Turku 42
Kunming 40
Montreal 39
Boardman 38
Falls Church 38
Johannesburg 36
Jiaxing 35
Rio de Janeiro 34
Chennai 32
Des Moines 32
Hải Dương 32
Dublin 31
Mexico City 31
Poplar 31
Shanghai 31
Stockholm 31
Toronto 31
Changsha 30
Nuremberg 29
Helsinki 27
Atlanta 26
Cagliari 26
London 26
Belo Horizonte 25
Denver 25
Baghdad 23
Salerno 23
Council Bluffs 22
Phoenix 22
San Francisco 22
Manchester 21
Hangzhou 20
Washington 20
Augusta 19
Biên Hòa 19
Brasília 19
Milan 19
Bangkok 18
Nocera Superiore 18
Indiana 17
Nairobi 17
Porto Alegre 17
Thái Bình 17
Thái Nguyên 17
Erbil 16
Buenos Aires 15
Can Tho 15
Guarulhos 15
Guayaquil 15
Ninh Bình 15
Totale 14.475
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Nome #
Association between DNA methylation profile and malignancy in follicular-patterned thyroid neoplasms 245
NCOA4 links iron bioavailability to DNA metabolism 181
D898_E901 RET Deletion Is Oncogenic, Responds to Selpercatinib, and Treatment Resistance Can Arise Via RET-Independent Mechanisms 178
A mutated p53 gene alters thyroid cell differentiation 176
A set of miRNAs participates in the cellular senescence program in human diploid fibroblasts 171
Mechanisms of RET mediated signal transduction 170
Autocrine stimulation by osteopontin plays a pivotal role in the expression of the mitogenic and invasive phenotype of RET/PTC-transformed thyroid cells. 169
UbcH10 overexpression may represent a marker of anaplastic thyroid carcinomas 165
Oncogene-induced senescence and its evasion in a mouse model of thyroid neoplasia 164
Identification of Novel Small Molecule Inhibitors of Oncogenic RET Kinase 164
NCOA4 inhibits initiation of DNA replication to maintain genome stability 156
A novel member of the BTB/POZ family, PATZ, associates with the RNF4 RING finger protein and acts as a transcriptional repressor 153
Thyroid targeting of the N-ras(Gln61Lys) oncogene in transgenic mice results in follicular tumors that progress to poorly differentiated carcinomas. 152
Mast cells induce epithelial-to-mesenchymal transition and stem cell features in human thyroid cancer cells through an IL-8-Akt-Slug pathway. 152
Analisi del profilo di espressione di microRNA nella senescenza cellulare 149
Mast cells have a protumorigenic role in human thyroid cancer. 148
Generation and characterization of novel monoclonal antibodies to the Ret receptor tyrosine kinase 147
The kinase inhibitor PP1 blocks tumorigenesis induced by RET oncogenes 146
Fragment-Based Discovery of a Dual pan-RET/VEGFR2 Kinase Inhibitor Optimized for Single-Agent Polypharmacology 146
Genetic Alterations in differentiated thyroid cancer:what can be expected for gene expression profiling of thyroid carcinomas 145
The Insulin Receptor Substrate (IRS)-1 recruits Phosphatidylinositol 3-Kinase to Ret: evidence for a competition between Shc and IRS-1 for the binding to Ret. 143
Targeted activity of the small molecule kinase inhibitor Pz-1 towards RET and TRK kinases 143
RET-mediated CD44 proteolysis promotes autonomous proliferation of thyroid cells 142
Chromatin and DNA methylation dynamics during retinoic acid-induced RET gene transcriptional activation in neuroblastoma cells. 142
Signal Transducer and Activator of Transcription 1 Plays a Pivotal Role in RET/PTC3 Oncogene-induced Expression of Indoleamine 2,3-Dioxygenase 1 139
NCOA4 Deficiency Impairs Systemic Iron Homeostasis 138
Bioisosteric discovery of npa101.3, a second-generation ret/vegfr2 inhibitor optimized for single-agent polypharmacology 134
MicroRNA deregulation in human thyroid papillary carcinomas. 130
Efficient inhibition of RET/papillary thyroid carcinoma oncogenic kinases by 4-amino-5-(4-chloro-phenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine (PP2). 130
ZD6474, an orally available inhibitor of KDR tyrosine kinase activity, efficiently blocks oncogenic RET kinases 130
Morphological ultrasound micro-imaging of thyroid in living mice. 129
The different RET-activating capability of mutations of cysteine 620 or cysteine 634 correlates with the multiple endocrine neoplasia type 2 disease phenotype. 129
Ultrasound-induced mechanical damage of cancer cell cytoskeleton causes disruption of nuclear envelope and activation of cGAS-STING 128
The RET receptor: function in development and dysfunction in congenital malformation. 128
Human papilloma virus 16E7 oncogene does not cooperate with ret/ptc 3 oncogene in the neoplastic transformation of thyroid cells in transgenic mice 127
RET activation and clinicopathologic features in poorly differentiated thyroid tumors. 126
The tyrosine kinase inhibitor ZD6474 blocks proliferation of RET mutant medullary thyroid carcinoma cells. 126
Extracellular superoxide dismutase is a thyroid differentiation marker downregulated in cancer. 125
Cross talk between the bombesin neuropeptide receptor and Sonic hedgehog pathways in small cell lung carcinoma 123
NCOA4 Links Iron Bioavailability to DNA Metabolism 123
Ret gene fusions in malignancies of the thyroid and other tissues 123
Biological role and potential therapeutic targeting of the chemokine receptor CXCR4 in undifferentiated thyroid cancer 121
RET/papillary thyroid carcinoma oncogenic signaling through the Rap1 small GTPase 120
Thyroid cell transformation inhibits the expression of a novel rat protein tyrosine phosphatase. 120
FOXM1 is a molecular determinant of the mitogenic and invasive phenotype of anaplastic thyroid carcinoma. 120
Activation of the Erk8 mitogen-activated protein (MAP) kinase by RET/PTC3, a constitutively active form of the RET proto-oncogene. 119
Receptor- and non-receptor tyrosine kinases induce processing of the amyloid precursor protein: role of the low-density lipoprotein receptor-related protein. 119
Novel candidate genes of thyroid tumourigenesis identified in Trk-T1 transgenic mice. 119
BAY 43-9006 inhibition of oncogenic RET mutants 118
Ras-mediated apoptosis of PC CL 3 rat thyroid cells induced by RET/PTC oncogenes. 118
Molecular mechanisms of RET activation in human cancer 118
NCOA4 transcriptional coactivator inhibits activation of DNA replication origins. 118
PTC is a novel rearranged form of the ret proto-oncogene and is frequently detected in vivo in human thyroid papillary carcinomas. 117
Dual effect on the RET receptor of MEN 2 mutations affecting specific extracytoplasmic cysteines. 117
A loss-of-function genetic screening identifies novel mediators of thyroid cancer cell viability 115
Antineoplastic ribonucleases selectively kill thyroid carcinoma cells via caspase-mediated induction of apoptosis 114
The TRK and RET tyrosine kinase oncogenes cooperate with ras in the neoplastic transformation of a rat thyroid epithelial cell line. 114
The RET kinase inhibitor NVP-AST487 blocks growth and calcitonin gene expression through distinct mechanisms in medullary thyroid cancer cells 112
Specific microRNAs are downregulated in human thyroid anaplastic carcinomas. 112
Highly selective toxic and proapoptotic effects of two dimeric ribonucleases on thyroid cancer cells compared to the effects of doxorubicin 112
OPN/CD44v6 overexpression in laryngeal dysplasia and correlation with clinical outcome. 112
TPA induces a block of differentiation and increases the susceptibility to neoplastic transformation of a rat thyroid epithelial cell line 112
RET/PTC1 oncogene signaling in PC Cl 3 thyroid cells requires the small GTP-binding protein Rho. 112
The importance of the RET gene in thyroid cancer and therapeutic implications 112
Overexpression of the Cytokine Osteopontin Identifies Aggressive Laryngeal Squamous Cell Carcinomas and Enhances Carcinoma Cell Proliferation and Invasiveness. 111
Cloning and characterization of H4 (D10S170), a gene involved in RET rearrangements in vivo. 111
Activation of the mTOR Pathway in Primary Medullary Thyroid Carcinoma and Lymph Node Metastases. 111
A potential pathogenetic mechanism for multiple endocrine neoplasia type 2 syndromes involves ret-induced impairment of terminal differentiation of neuroepithelial cells. 111
Tyrosines 1015 and 1062 are in vivo autophosphorylation sites in ret and ret-derived oncoproteins. 110
A dual mechanism of activation of the sonic hedgehog pathway in anaplastic thyroid cancer: Crosstalk with RAS-BRAF-MEK pathway and ligand secretion by tumor stroma 110
The neuron-specific Rai (ShcC) adaptor protein inhibits apoptosis by coupling Ret to the phosphatidylinositol 3-kinase/Akt signaling pathway. 109
HMGA2 mRNA expression correlates with the malignant phenotype in human thyroid neoplasias. 108
RET ONCOGENE ACTIVATION IN HUMAN THYROID NEOPLASMS IS RESTRICTED TO THE PAPILLARY CANCER SUBTYPE 108
Molecular mechanism of 17-allylamino-17-demethoxygeldanamycin (17-AAG)-induced AXL receptor tyrosine kinase degradation. 108
I geni oncosoppressori in "Patologia Generale" IV Ed, Pontieri-Russo-Frati 107
CCDC6 represses CREB1 activity by recruiting histone deacetylase 1 and protein phosphatase 1. 107
TWIST1 plays a pleiotropic role in determining the anaplastic thyroid cancer phenotype. 107
Rat protein tyrosine phosphatase eta physically interacts with the PDZ domains of syntenin. 106
microRNA expression during the induction of cellular senescence. 106
A cell proliferation and chromosomal instability signature in anaplastic thyroid carcinoma. 105
CD97 amplifies LPA receptor signaling and promotes thyroid cancer progression in a mouse model. 105
Anterior gradient protein 2 promotes survival, migration and invasion of papillary thyroid carcinoma cells 105
Roles of mast cells and their mediators in human thyroid carcinomas. 103
High frequency of activation of tyrosine kinase oncogenes in human papillary thyroid carcinoma 103
Efficient inhibition of RET/papillary thyroid carcinoma oncogenic kinases by 4-amino-5-(4-chloro-phenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine (PP2) 103
The molecular basis for RET tyrosine-kinase inhibitors in thyroid cancer 103
Discovery of N-Trisubstituted Pyrimidine Derivatives as Type I RET and RET Gatekeeper Mutant Inhibitors with a Novel Kinase Binding Pose 103
An adenovirus carrying the rat protein tyrosine phosphatase eta suppresses the growth of human thyroid carcinoma cell lines in vitro and in vivo. 102
BRAF is a therapeutic target in aggressive thyroid carcinoma. 102
A new mechanism of BRAF activation in human thyroid papillary carcinomas 101
High mobility group I (Y) proteins bind HIPK2, a serine-threonine kinase protein which inhibits cell growth. 101
Activated RET oncogene products induce maturation of xenopus oocytes. 101
Signaling pathways and mechanism of action of the extracellular superoxide dismutase, SOD3. 100
20 years of RET/PTC in thyroid cancer: clinico-pathological correlations. 99
Discovery of pyrazolo-thieno[3,2-d]pyrimidinylamino-phenyl acetamides as type-II pan-tropomyosin receptor kinase (TRK) inhibitors: Design, synthesis, and biological evaluation 98
Potent mitogenicity of the RET/PTC3 oncogene correlates with its prevalence in tall-cell variant of papillary thyroid carcinoma 97
Activated RET/PTC oncogene elicits immediate early and delayed response genes in PC12 cells. 97
45th Annual Meeting of the Italian Cancer Society 96
Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer. 96
Loss of the CBX7 gene expression correlates with a highly malignant phenotype in thyroid cancer. 96
Totale 12.452
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Categoria #
all - tutte 90.566
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 90.566
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021211 0 0 0 0 0 0 0 0 0 25 171 15
2021/20221.678 32 24 18 13 23 62 32 72 374 76 255 697
2022/20231.878 352 113 21 203 194 224 6 189 297 149 98 32
2023/20241.271 50 193 168 91 65 103 32 163 29 20 265 92
2024/20257.315 466 612 72 39 129 376 813 400 728 795 2.205 680
2025/202612.217 1.614 896 1.187 1.091 2.142 561 1.450 894 1.696 686 0 0
Totale 28.092