Melanoidins are Maillard reaction products similar to dietary fiber but their effect on food intake was under-investigated. A randomized, crossover study of 14 healthy subjects investigated whether melanoidins modulated energy intake and affected the postprandial dynamics of 21 gut-brain modulators of appetite including gastrointestinal peptides, endocannabinoids, N-acylethanolamines and neuropeptides. At breakfast the subjects consumed a bread enriched with either 3 g coffee melanoidins (CM), 3 g bread melanoidins (BM), or a conventional bread (CT). Energy intakes at lunch and throughout the day were measured, while appetite sensations and blood samples were collected before and 30, 60, 120, and 180 min after breakfast. Compared to CT, CM significantly reduced daily energy intake by 26%. CM lowered blood glucose peak, insulin, α-melanocyte stimulating hormone, orexin-A, β-endorphin, and blunted the response of three N-acylethanolamines versus BM. Coffee melanoidins at breakfast reduces daily energy intake and modulates postprandial glycemia and other biomarkers.
Melanoidins from coffee and bread differently influence energy intake: A randomized controlled trial of food intake and gut-brain axis response / Walker, J. M.; Mennella, I.; Ferracane, R.; Tagliamonte, S.; Holik, A. -K.; Holz, K.; Somoza, M. M.; Somoza, V.; Fogliano, V.; Vitaglione, P.. - In: JOURNAL OF FUNCTIONAL FOODS. - ISSN 1756-4646. - 72:(2020), p. 104063. [10.1016/j.jff.2020.104063]
Melanoidins from coffee and bread differently influence energy intake: A randomized controlled trial of food intake and gut-brain axis response
Walker J. M.;Mennella I.;Ferracane R.;Tagliamonte S.;Vitaglione P.
2020
Abstract
Melanoidins are Maillard reaction products similar to dietary fiber but their effect on food intake was under-investigated. A randomized, crossover study of 14 healthy subjects investigated whether melanoidins modulated energy intake and affected the postprandial dynamics of 21 gut-brain modulators of appetite including gastrointestinal peptides, endocannabinoids, N-acylethanolamines and neuropeptides. At breakfast the subjects consumed a bread enriched with either 3 g coffee melanoidins (CM), 3 g bread melanoidins (BM), or a conventional bread (CT). Energy intakes at lunch and throughout the day were measured, while appetite sensations and blood samples were collected before and 30, 60, 120, and 180 min after breakfast. Compared to CT, CM significantly reduced daily energy intake by 26%. CM lowered blood glucose peak, insulin, α-melanocyte stimulating hormone, orexin-A, β-endorphin, and blunted the response of three N-acylethanolamines versus BM. Coffee melanoidins at breakfast reduces daily energy intake and modulates postprandial glycemia and other biomarkers.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
